Antibiotics that act on nucleic acids Flashcards
What is the suffix of quinolones? Their MOA and spectrum?
Story to memorize it?
Suffix: -floxacin
MOA: inhibits DNA gyrase
Spectrum: atypical & broad
Story: the queen was flexing, she loved gyros; the atypical and broad kind
Which quinolones are termed “respiratory quinolones”?
Story?
Gemifloxacin
Levofloxacin
Moxifloxacin
Story: breath in the levitating gems and moth
Which quinolones cover pseudomonas?
Story?
Levofloxacin
Ciprofloxacin
Story: mona was sipping and levitating with the queen
What spectrum does moxifloxacin cover?
Story?
G +ve and anaerobic
Story: the moth was +ve and very queit it didn’t breath
Which quinolone is not used for UTI? Why?
Moxifloxacin
Doesn’t reach the urine, low concentration in the urine
Which quinolone covers MRSA?
Story?
Delafloxacin
Story: Diala had mercy with the queen
Adverse effects of quinolones?
Story?
- tendon inflammation/rupture
- myasthenia gravis
- hypoglycemia/hyperglycemia
- peripheral neuropathy
- CNS side effects: seizures, suicidal thoughts, hallucinations
- photosensitivity
- avoid use in: children, pregnancy, breastfeeding
- QT prolongation
Story: the queen couldn’t walk (tendon inflam/rupture), she had diabetes (hypo and hyperglycemia) which led to peripheral neuropathy, she got cns effects when exposed to the 🌞, the queen avoided any children, becoming pregnant and breastfeeding, she also liked cuties (QT prolongation)
Quinolones are avoided in? Why?
Avoided in children, pregnancy, breastfeeding 🤱
Why? Musculoskeletal toxicity, chelation with Ca+2 which affects muscle and bone growth
Drug interactions of quinolones?
Story?
- not used with polyvalent cations (ca+2, mg+2, al+3, zn+2)
Why? Chelation
Example? Antacids
- increases effect of warfarin
- increases effect of hypoglycemic drugs
- probencid & nsaid increase quinolone conc in blood (decrease elim)
Story: the queen doesn’t use things twice, she increases war and decreases sugar for people, ben was a pro n’ said he liked her
Metronidazole/Tinidazole
Group? MOA? Spectrum? Adverse effects? Contraindications?
Story?
Group: quinolones
MOA: DNA 🧬 breakage
Spectrum: anaerobic, antiprotozoal
Adverse effects: metallic taste, skin reactions, ⬆️ INR with warfarin
Contraindications: pregnancy 🤰, alcohol 🍺 (disulfuram type reaction)
Story: the metro 🚇 was made of tin and it broke down the dna 🧬 tracks, it was a pro and didn’t use oxygen
The metro had a metallic taste on the tongue and a reaction on the skin, it ⬆️ inner war
Pregnant 🤰 women can’t ride on metros 🚇 or drink alcohol
Fidaxomicin
Group?
MOA?
Use?
Story?
Group: quinolones
MOA: acts on nucleic acids by inhibiting RNA polymerase
Use: treatment of clostridium defficile
Story: fida and rana we close, they feed their guts
Rifaximicin
Group?
MOA?
Use?
Story?
Group: quinolones
MOA: acts on nucleic acids by inhibiting RNA polymerase
Use: treatment of traveler’s diarrhea
Story: rifa and rana traveled and got diarrhea
Rifampin
Group?
MOA?
Use?
Adverse effects?
Story?
Group: quinolones
MOA: acts on nucleic acids by inhibiting RNA polymerase
Use: treatment of myobacterium TB, leprosy, g -ve (neissera, haemophilus influenza)
Adverse effects: red discoloration of urine and sweat
Story: the family and rana loved red lipstick 💄, rana posted #tb about her lips 👄, she was necessarily -ve and had influenza
