Antibiotics That Act On Cell Membrane Flashcards
What are the antibiotics that act on cell membrane?
Polymixin
Daptomycin
Lipoglycopeptides “-vancin”
What spectrum does daptomycin cover?
G+ve (MRSA, VRSA)
Daptomycin is not used in the treatment of? Why?
Pneumonia
Drug is inactivated by lung surfactant
Adverse effects of daptomycin?
Myopathy & rhabdomylosis (monitor CPK, if it ⬆️ dicont drug)
Falsely ⬆️ inr and pr (no bleeding risk)
Drug interactions of daptomycin?
Not used with any drug that causes myopathy “statins”
List polymixin drugs:
Polumixin B
Colistin
Polymixins are used for? Why?
MDR bacteria in nosocomial infections ONLY
Why? ⬆️ toxicity
Adverse effects of polymixins?
Nephrotoxic
Neurotoxic
Drug interactions of polymixins?
Not used with nephrotoxic and/or neurotoxic drugs