Antibiotics That Act On Cell Membrane Flashcards

1
Q

What are the antibiotics that act on cell membrane?

A

Polymixin

Daptomycin

Lipoglycopeptides “-vancin”

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2
Q

What spectrum does daptomycin cover?

A

G+ve (MRSA, VRSA)

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3
Q

Daptomycin is not used in the treatment of? Why?

A

Pneumonia

Drug is inactivated by lung surfactant

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4
Q

Adverse effects of daptomycin?

A

Myopathy & rhabdomylosis (monitor CPK, if it ⬆️ dicont drug)

Falsely ⬆️ inr and pr (no bleeding risk)

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5
Q

Drug interactions of daptomycin?

A

Not used with any drug that causes myopathy “statins”

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6
Q

List polymixin drugs:

A

Polumixin B

Colistin

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7
Q

Polymixins are used for? Why?

A

MDR bacteria in nosocomial infections ONLY

Why? ⬆️ toxicity

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8
Q

Adverse effects of polymixins?

A

Nephrotoxic

Neurotoxic

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9
Q

Drug interactions of polymixins?

A

Not used with nephrotoxic and/or neurotoxic drugs

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