Antibiotics

Question 1

Beta lactam examples

Answer 1

Penicilin
Amoxicillin
Flucoxacilin 
Cephlasporins
cefloxacin

Question 2

Beta lactam mechanism

Answer 2

Beta lactam ring binds PBP cell wall cant synthesize cell death due instability

Question 3

Aminoglyceride examples

Answer 3

Streptomycin
Gentamycin - comm acquired pneamonia
Tobramycin
Amikacin

Question 4

Aminoglyceride mechanism

Answer 4

Penetrate bacterial cell wall via porin channels bind 30s ribosomal subunit interfere initiation complex - misreading genetic code * interruption normal bactericidal protein synthesis

Question 5

Glycopeptides examples

Answer 5

Vancomycin

Question 6

Glycopeptides mechanism

Answer 6

inhibit cell wall synthesis binds d alanine terminal of peptide chain during cell wall synthesis * inhibit transpeptidase prevent elongation + cross linking of peptidogycan matrix

Question 7

Quinolones example

Answer 7

Ciprofloxin

Levofloxin

Question 8

Quinolones mechanism

Answer 8

inhibits DNA gyrase (topsoimerase II) formation quinolone DNA gyrase complex - inhibts bacterial topisomerase IV preventing relaxation of super coiled DNA

Question 9

Pseudomonas

Answer 9

aerobic 
gram-negative 
motile
rods that
oxidase positive 
lactose nonfermenters

Question 10

tetracylines examples

Answer 10

DOXYCLINE

Question 11

Tetracycline mechanism

Answer 11

Bind 30s ribosome prevent addition aa on growing peptide chain + chelate cations necc enzymatic action

Question 12

Macrolides examples

Answer 12

clarithromycin

Eryhtromycin

Question 13

Macrolides mechanism

Answer 13

protein synthesis inhibitor binds 50s ribosomal sununit inhibit polypeptide chain elongation + protien synthesis inhibition

Question 14

Sulfonamides mechansim

Answer 14

analogue PABA inhibit bacterial folate synthase - formation folate inhibited - metabolic injurious

Question 15

tetracylines examples

Answer 15

Doxycline

Question 16

Tetracycline mechanism

Answer 16

binds 30s ribsome prevents addtion AA on growing peptide chain. Chelate cation necc enzymatic action

Question 17

Macrolides examples

Answer 17

Azithromycin
Clarithromycin
Erthyromycin

Question 18

Macrolides mechanism

Answer 18

Binds 50s ribosomal sub unit inhibit polypeptide chain elongation+ protein synthesis -> cant grow

Question 19

Sulfonamides mechansim

Answer 19

Bacteria synthesize own folic acid - need PABA - sulfonamides structual analogue PABA - inhibit bacterial folate synthase -> inhibited formation folate
metabolic damage

Question 20

Clarithromycin

Answer 20

Macrolide

Question 21

AMINOGLYCERIDES SE

Answer 21

OTOTOXCITITY nephrotoxicity + neuromuscular blockade

Question 22

Drugs community acquired pseudomonas

Answer 22

Topical - aminoglyceride gentymicin
Oral therapy - fluroquinolone- ciprofloxacin
OPAT - 3rd gen cephalsporin-ceftazamide
Tazocin

Question 23

TAZOCIN

Answer 23

Broad spec penicillin
Piperacillin - extended spectrum beta lactam
Tazobactam - beta lactamase inhibtor

Question 24

Drugs hospital acquired Pseudomonas

Answer 24

Piperacillin
Caftazidime
Gentamycin
Meropenem

Question 25

CF inhaled drugs

Answer 25

Tobramycin Colistin atrezonam

Question 26

CF parental drugs

Answer 26

Ceftazidimide Tobramycin Ciprofloxacin

Question 27

LRTI drug community

Answer 27

Amoxicillin or doxyclycine

Question 28

LRTI hospital

Answer 28

Co- amoxiclav Doxycliclin Vancomycin supsect MRSA Vent associated co-trimoxazole or tazocin

Question 29

Co -trimoxazole

Answer 29

Sulfamethoxazole and trimethoprim