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Year 2 > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Beta lactam examples

A 
Penicilin
Amoxicillin
Flucoxacilin 
Cephlasporins
cefloxacin
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2
Q

Beta lactam mechanism

A

Beta lactam ring binds PBP cell wall cant synthesize cell death due instability

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3
Q

Aminoglyceride examples

A

Streptomycin
Gentamycin - comm acquired pneamonia
Tobramycin
Amikacin

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4
Q

Aminoglyceride mechanism

A

Penetrate bacterial cell wall via porin channels bind 30s ribosomal subunit interfere initiation complex - misreading genetic code * interruption normal bactericidal protein synthesis

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5
Q

Glycopeptides examples

A

Vancomycin

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6
Q

Glycopeptides mechanism

A

inhibit cell wall synthesis binds d alanine terminal of peptide chain during cell wall synthesis * inhibit transpeptidase prevent elongation + cross linking of peptidogycan matrix

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7
Q

Quinolones example

A

Ciprofloxin

Levofloxin

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8
Q

Quinolones mechanism

A

inhibits DNA gyrase (topsoimerase II) formation quinolone DNA gyrase complex - inhibts bacterial topisomerase IV preventing relaxation of super coiled DNA

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9
Q

Pseudomonas

A 
aerobic 
gram-negative 
motile
rods that
oxidase positive 
lactose nonfermenters
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10
Q

tetracylines examples

A

DOXYCLINE

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11
Q

Tetracycline mechanism

A

Bind 30s ribosome prevent addition aa on growing peptide chain + chelate cations necc enzymatic action

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12
Q

Macrolides examples

A

clarithromycin

Eryhtromycin

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13
Q

Macrolides mechanism

A

protein synthesis inhibitor binds 50s ribosomal sununit inhibit polypeptide chain elongation + protien synthesis inhibition

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14
Q

Sulfonamides mechansim

A

analogue PABA inhibit bacterial folate synthase - formation folate inhibited - metabolic injurious

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15
Q

tetracylines examples

A

Doxycline

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16
Q

Tetracycline mechanism

A

binds 30s ribsome prevents addtion AA on growing peptide chain. Chelate cation necc enzymatic action

17
Q

Macrolides examples

A

Azithromycin
Clarithromycin
Erthyromycin

18
Q

Macrolides mechanism

A

Binds 50s ribosomal sub unit inhibit polypeptide chain elongation+ protein synthesis -> cant grow

19
Q

Sulfonamides mechansim

A

Bacteria synthesize own folic acid - need PABA - sulfonamides structual analogue PABA - inhibit bacterial folate synthase -> inhibited formation folate
metabolic damage

20
Q

Clarithromycin

A

Macrolide

21
Q

AMINOGLYCERIDES SE

A

OTOTOXCITITY nephrotoxicity + neuromuscular blockade

22
Q

Drugs community acquired pseudomonas

A

Topical - aminoglyceride gentymicin
Oral therapy - fluroquinolone- ciprofloxacin
OPAT - 3rd gen cephalsporin-ceftazamide
Tazocin

23
Q

TAZOCIN

A

Broad spec penicillin
Piperacillin - extended spectrum beta lactam
Tazobactam - beta lactamase inhibtor

24
Q

Drugs hospital acquired Pseudomonas

A

Piperacillin
Caftazidime
Gentamycin
Meropenem

25
Q

CF inhaled drugs

A

Tobramycin
Colistin
atrezonam

26
Q

CF parental drugs

A

Ceftazidimide
Tobramycin
Ciprofloxacin

27
Q

LRTI drug community

A

Amoxicillin or doxyclycine

28
Q

LRTI hospital

A

Co- amoxiclav
Doxycliclin
Vancomycin supsect MRSA
Vent associated co-trimoxazole or tazocin

29
Q

Co -trimoxazole

A

Sulfamethoxazole and trimethoprim

Year 2 (12 decks)

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