antibiotics Flashcards
Which of the following statements is False
a. Inhibit COX synthase and therefore prostaglandin
b. Both Cox-1 and COX-2 selective NSAID will be cytoprotective. Only COX1 is cytoprotective
c. Cytokines specifically induce COX-2
d. Flunixin when injected intramuscular can potentially cause severe myonecrosis
Both Cox-1 and COX-2 selective NSAID will be cytoprotective. Only COX1 is cytoprotective
Which of the following statements is False
a. Fentanyl in the form of a patch has a delay in clinical efficacy b. Ketamine can potentially cause dissociative CNS signs at higher doses.
b. Ketamine can potentially cause dissociative CNS signs at higher doses.
c. NSAID have good analgesic properties. NSAIDs do not have analgesia properties.
d. NSAIDs have indirect anti-endotoxic properties because of their anti-inflammatory properties
c. NSAID have good analgesic properties. NSAIDs do not have analgesia properties.
Which of the following statements is False
- Cmax may be used to determine whether abnormal signs displayed by an animal after antibiotic treatment are associated with side
effects/toxicity of the antibiotic used
- Volume of distribution of an antibiotic is dependent on its bioavailability, ionization and protein binding in the blood.
- A large volume of distribution means that most of the antibiotic is trapped in the blood
- The amount of free antibiotic in the blood can be increased by increasing the dose
A large volume of distribution means that most of the antibiotic is trapped in the blood
Which of the following antibiotics cannot be used extra label based on dosage and route of administration
- Enrofloxacin
- Sulfonamides
- Tulathromycin
- Ceftiofur
- Ceftiofur
Which of the following statements are False
- Ampicillin is less susceptible to beta-lactamase compared to penicillin
- Cephalosporin has a wider gram negative spectrum compared to synthetic penicillin
3 ELDU of cephalosporin (Ceftiofur) allows for treatment of systemic conditions outside the labeled conditions in major
species
- ELDU of cephalosporin (ceftiofur) allows the IV route of administration in Food animal species
- ELDU of cephalosporin (ceftiofur) allows the IV route of administration in Food animal species
- Which of the following statements are False
a. Xylazine may cause a drop in blood pressure leading to inadequate tissue perfusion and heat dissipation
b. Xylazine may cause a osmotic diuresis
c. Level of sedation is very predictable after IM administration of Xylazine
d. Tolazoline is a alpha2-antagonist which is preferably given IM
c. Level of sedation is very predictable after IM administration of Xylazine
Which of the following statements is False
- Bactericidal action more important than intracellular concentration
- Aminoglycosides are dependent on an active transport system for complete absorption
- Protein binding does not affect antibiotics crossing cell membranes
- Propylene glycol commonly used as a base can cause a drop in blood pressure through histamine release
- Protein binding does not affect antibiotics crossing cell membranes
Which of the following statements is False
- Cephalosporins more susceptible to beta lactamases compared to synthetic penicillin
- Fluoroquinolones are bactericidal through inhibition of DNA – gyrase
- Fluoroquinolones are effective against gram negative bacteria including E coli and Salmonella
- ELDU of fluoroquinolones is illegal and may not be stored on Dairy farms
1.Cephalosporins more susceptible to beta lactamases compared to synthetic penicillin
Which antibiotic PK factor/property listed below would be most beneficial to treat a intracellular infection in the lung
- Large volume of distribution.
- Long half life
- Low protein binding
4 positive culture and sensitivity
1.Large volume of distribution.
Which of the following statements is False
- Long acting cephalosporin is labeled for bovine respiratory disease metaphylaxis
- Mode of action of cephalosporin is inhibition of protein synthesis
- Tetracyclines have an extended spectrum which include erlichia and mycoplasma
- Tetracyclines are bactericidal by inhibition of cell wall development
- Tetracyclines are bactericidal by inhibition of cell wall development
Which of the following statement regarding penicillin is False
- Penicillin is highly effective for use in joint infections and osteomyelitis
- Ampicillin is also excrete through the biliary system and as such is used against gram negative enterobacteria.
- Penicillin inactivates the binding protein to form the cell wall of gram positive bacteria
- Penicillin works synergistically with aminoglycosides
- Penicillin is highly effective for use in joint infections and osteomyelitis
Which of the following statements are False
- Floroquinelones have better intracellular penetration than beta lactams
- Danofloxacin is labeled for use in beef cattle and all calves (excluding veal calves).
- Liver elimination of the macrolides results in entero-hepatic cycle with long terminal half life
- Macrolides are bactericidal through binding with 50S ribosome
- Macrolides are bactericidal through binding with 50S ribosome
Which of the following statements is False
a. Pigs and camelids are stoic with regards to pain making assessment of presence and severity of pain difficult in these species
b. Vocalization in a male goat is often associated with urolithiasis
c. “Hypersensitization” is mediated through glutamate and NMDA receptors
d. Lidocaine prevent ddepolarization of sensory nociceptors by primarily by blocking calcium channels.
Lidocaine prevent ddepolarization of sensory nociceptors by primarily by blocking calcium channels.
Which of the following statements regarding penicillin is False
- Penicillin is not active against penicillinase-producing bacteria
- Penicillin is not active against organisms which cause alterations in the penicillin-binding protein
- High dose helps with intracellular penetration
- Bactericidal activity independent of dose
- High dose helps with intracellular penetration
Which of the following groups would be most effective against anerobic intracellular infection in tissue requiring a medium volume of
distribution.
- Beta lactam –equal concentration inside and outside cell/bactericidal/anaerobic
- Quinolones – higher concentration inside the cell/bactericidal/broad spectrum
- Macrolides – highest capacity for accumulation in cell through endocytosis/bacteriostatic/broad spectrum
- Florfenicol/flunixin – higher concentration inside cell/bacteriostatic/ broad spectrum/ anti-inflammatory
- Macrolides – highest capacity for accumulation in cell through endocytosis/bacteriostatic/broad spectrum