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Pharm Exam 4 > Antibiotics 4 > Flashcards

Antibiotics 4 Flashcards

1
Q
  • Uncomplicated infection organisms?
  • Antibiotic?
  • If alergy?
A
  • Staph aureus & Strep pyogenes (GRAM +)
  • penicillin (ampicillin - broad) OR 1st gen ceph (cephalexin)
  • Vancomycin OR clindamycin
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2
Q
  • What are complicated infections?
  • Complicated infection organisms?
  • Antibiotics?
A
  • burns, diabetes melitus, pressure ulcers, trauma/surgery…
  • E Coli & Pseudomonoas aeruginosa
  • Penicillin + Lactamase inhibitor
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3
Q

What to give for MRSA infections?

A

vancomycin
linezolid
daptomycin

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4
Q

osteomyelitis

  • organisms?
  • epiric tx?
A

-Staph aureus OR staphylococci

  • vancomycin
  • Cephalosporins (ceftriaxone or cefepime) –> broader
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5
Q

Orthopedic Surgeries or vertebral infections

  • organism?
  • tx drug?
A
  • E Coli OR P. aeruginosa

- Penicillin + lactamase inh

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6
Q

Septic arthritis

  • organsim?
  • Empiric Tx?
  • MRSA Tx?
A
  • S aureus
  • S Pyogens
  • Strep Pneumo
  • N Gonorrhoeae
  • Epiric=cefriaxone
  • MRSA=vancomycin, daptomycin, linezolin
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7
Q

Prosthetic joint infection

  • organism?
  • tx drug?
A
  • Staph aureus OR Staphylococci

- Rifampin

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8
Q

Acute sinusitis/Chronic bronchitis

  • oganisms
  • tx?
A
  • S. Pneumo
  • H influenzae
  • moraxella catarrhalis

-penicillin + lactamase inh (Amoxicillin + clavulanate)

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9
Q

Pharyngitis

  • organisms?
  • tx?
A

-A. Streptococci

  • penicillin
  • amoxicillin
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10
Q

Upper respiratory infection think what drug?

A

amoxicilin

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11
Q

Community acquired bacterial pneumonia

  • -organisms?
  • ambulatory?
  • hospitalization?
  • MRSA?
A
  • S pneumoniae
  • mycoplasma pneumoniae
  • amb=Macrolide (erythromycin, azithromycin, clarithromycin)
  • hosp=Beta-lactam+macrolide
  • MRSA=vanco or linezolid
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12
Q

Hospital acquired, Healthcare associated ventilator-associated pneumonia

  • organisms?
  • empiric
  • MRSA?
A
  • E coili
  • enterobacter
  • serratia
  • P aeruginosa
  • Acinetobacter
  • MRSA
  • epiric=Ceftriaxone
  • MRSA= vanco or linezolid
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13
Q

uncomplicated UTI

  • organsims?
  • cystitis tx?
  • pyelonephritis tx?
A

-E Coli

  • cystitis=trimethoprim/sulfamethoxazole
  • Polyneph=TMP-SMX OR Fluoroquinolone
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14
Q

Complicated UTI

  • organisms?
  • tx?
A
  • S aureus
  • resistant Gram neg
  • enterococci
  • Fluoroquinolones
  • TMP-SMX
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15
Q

Prostatitis

  • organisms?
  • tx?
A

-enteric Gram neg (e Coli, Proteus, klebsiella, P aeruginosa, Enterococcus

  • Fluoroquinolones
  • TMP-SMX
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16
Q

Intra-abdominal infections (cholangitis/diverticulitis)

  • organsism?
  • tx?
A
  • E Coli,
  • Kelbsiella
  • proteus
  • bacteroides fragilis

-ticarcillin + clavulanate

17
Q

Antibiotic associated GI infection-

  • what drugs are these patients on?
  • organism?
  • tx?
A
  • clindamycin, fluoroquinolones, broad spec penicillin, broad spec cephs
  • C difficile (gram+) infection
  • moderate=metronidazole (for anaerobics)
  • severe=vancomycin
18
Q

Meningitis - community acquired

  • ogansims?
  • tx?
A
  • S. Pneumo
  • N meningiditidis

->2yo = ceftriaxone OR cefotaxime + vancomycin

19
Q

Neonatal meningitis

  • oganisms?
  • tx?
A
  • GBS
  • Gram neg enteric
  • L monocytogenes

-<2yo = ampicillin + cephalosporin w/ or w/out gentamicin

20
Q

Serious sepsis syndrome

-tx?

A
  • Empiric based on specifics of infection

- 3rd or 4th ceph (cefepime) + vancomycin

21
Q

Serious endocarditis

  • organisms?
  • tx?
A
  • staph
  • strep

-ceftriaxone +vancomycin

22
Q

Serious fever and neuropenia

  • organsims
  • empric tx?
A
  • gram pos (from catheter)
  • gram neg = greatest threat

-empiric = ciprofloxacin + Amoxicilli/clavulanate

23
Q

Enterococci

  • why tx differently?
  • good tx?
A
  • resistant to ampicillins, gentamicin, streptomycin, and vancomycin
  • give: Linezolid; daptomycin; tigecycline
24
Q

Gram neg Bacteria (P Aeruginosa and Acinetobacter)

  • why treat differently?
  • good tx?
A

-gram negatives can express extended spectrum beta-lactamases (ESBL) or carbapenemases

  • ESBL = imipenem or meropenem (carbapenems)
  • Carbapenemases = polymyxin B OR tigecycline

Pharm Exam 4 (10 decks)

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