Antibiotics 4 Flashcards
- Uncomplicated infection organisms?
- Antibiotic?
- If alergy?
- Staph aureus & Strep pyogenes (GRAM +)
- penicillin (ampicillin - broad) OR 1st gen ceph (cephalexin)
- Vancomycin OR clindamycin
- What are complicated infections?
- Complicated infection organisms?
- Antibiotics?
- burns, diabetes melitus, pressure ulcers, trauma/surgery…
- E Coli & Pseudomonoas aeruginosa
- Penicillin + Lactamase inhibitor
What to give for MRSA infections?
vancomycin
linezolid
daptomycin
osteomyelitis
- organisms?
- epiric tx?
-Staph aureus OR staphylococci
- vancomycin
- Cephalosporins (ceftriaxone or cefepime) –> broader
Orthopedic Surgeries or vertebral infections
- organism?
- tx drug?
- E Coli OR P. aeruginosa
- Penicillin + lactamase inh
Septic arthritis
- organsim?
- Empiric Tx?
- MRSA Tx?
- S aureus
- S Pyogens
- Strep Pneumo
- N Gonorrhoeae
- Epiric=cefriaxone
- MRSA=vancomycin, daptomycin, linezolin
Prosthetic joint infection
- organism?
- tx drug?
- Staph aureus OR Staphylococci
- Rifampin
Acute sinusitis/Chronic bronchitis
- oganisms
- tx?
- S. Pneumo
- H influenzae
- moraxella catarrhalis
-penicillin + lactamase inh (Amoxicillin + clavulanate)
Pharyngitis
- organisms?
- tx?
-A. Streptococci
- penicillin
- amoxicillin
Upper respiratory infection think what drug?
amoxicilin
Community acquired bacterial pneumonia
- -organisms?
- ambulatory?
- hospitalization?
- MRSA?
- S pneumoniae
- mycoplasma pneumoniae
- amb=Macrolide (erythromycin, azithromycin, clarithromycin)
- hosp=Beta-lactam+macrolide
- MRSA=vanco or linezolid
Hospital acquired, Healthcare associated ventilator-associated pneumonia
- organisms?
- empiric
- MRSA?
- E coili
- enterobacter
- serratia
- P aeruginosa
- Acinetobacter
- MRSA
- epiric=Ceftriaxone
- MRSA= vanco or linezolid
uncomplicated UTI
- organsims?
- cystitis tx?
- pyelonephritis tx?
-E Coli
- cystitis=trimethoprim/sulfamethoxazole
- Polyneph=TMP-SMX OR Fluoroquinolone
Complicated UTI
- organisms?
- tx?
- S aureus
- resistant Gram neg
- enterococci
- Fluoroquinolones
- TMP-SMX
Prostatitis
- organisms?
- tx?
-enteric Gram neg (e Coli, Proteus, klebsiella, P aeruginosa, Enterococcus
- Fluoroquinolones
- TMP-SMX
Intra-abdominal infections (cholangitis/diverticulitis)
- organsism?
- tx?
- E Coli,
- Kelbsiella
- proteus
- bacteroides fragilis
-ticarcillin + clavulanate
Antibiotic associated GI infection-
- what drugs are these patients on?
- organism?
- tx?
- clindamycin, fluoroquinolones, broad spec penicillin, broad spec cephs
- C difficile (gram+) infection
- moderate=metronidazole (for anaerobics)
- severe=vancomycin
Meningitis - community acquired
- ogansims?
- tx?
- S. Pneumo
- N meningiditidis
->2yo = ceftriaxone OR cefotaxime + vancomycin
Neonatal meningitis
- oganisms?
- tx?
- GBS
- Gram neg enteric
- L monocytogenes
-<2yo = ampicillin + cephalosporin w/ or w/out gentamicin
Serious sepsis syndrome
-tx?
- Empiric based on specifics of infection
- 3rd or 4th ceph (cefepime) + vancomycin
Serious endocarditis
- organisms?
- tx?
- staph
- strep
-ceftriaxone +vancomycin
Serious fever and neuropenia
- organsims
- empric tx?
- gram pos (from catheter)
- gram neg = greatest threat
-empiric = ciprofloxacin + Amoxicilli/clavulanate
Enterococci
- why tx differently?
- good tx?
- resistant to ampicillins, gentamicin, streptomycin, and vancomycin
- give: Linezolid; daptomycin; tigecycline
Gram neg Bacteria (P Aeruginosa and Acinetobacter)
- why treat differently?
- good tx?
-gram negatives can express extended spectrum beta-lactamases (ESBL) or carbapenemases
- ESBL = imipenem or meropenem (carbapenems)
- Carbapenemases = polymyxin B OR tigecycline
