Antibiotics Flashcards
Methicillin and Oxacillin are what kind of antibiotics
Bacitracins
What are the mode of action of antibiotics part of bacitracin group?
Inhibit the synthesis of peptidoglycan in cell wall.
Beta-lactam and beta-lactamases are apart of what group of antibiotics?
Bacitracin
What is an example of a beta-lactamase inhibitor?
Clavulanic acid
What is the purpose of using beta-lactams and beta-lactamases together?
The combination restores the activity of beta-lactam in beta-lactamase producing organisms.
Glycopeptides and Lipoglycopeptides are what kind of antibiotics?
Polymyxins B
What is the mode of action of antibiotics which fall under Polymyxins B?
Interfere with the phospholipid layer in the cell wall, causing leaking of intracellular components.
Gentamycin and tobramycin are examples of what group of antibiotics?
Aminoglycosides
What is the mode of action of quinolones?
Inhibition of DNA gyrase.
What is the mode of action of Rifampin?
Inhibit DNA dependent RNA polymerase.
What is the mode of action of Aminoglycosides?
Irreversibly bins to the 30s rRNA subunit to prevent mRNA translation.
What is the mode of action of tetracyclines?
Irreversibly bins to the 30s rRNA subunit to prevent attachment to tRNA .
What is the mode action of macrolides?
Irreversibly bins to the 50s rRNA subunit to prevent elongation of the polypeptide chain.
What is the mode action of Chloramphericols?
Irreversibly bins to the 50s rRNA subunit to prevent elongation of the polypeptide chain.
What is the mode of action of clindamycins?
Irreversibly bins to the 50s rRNA subunit to prevent elongation of the polypeptide chain.
What is the mode of action of metronidazole?
Breaks DNA strands
What is the mode of action of Nitrofurantoin?
Targets protein and enzyme synthesis to damage DNA
What is the mode of action of sulfonamides, PAS, sulfone, Trimethoprim.
Inhibition of folic acid synthesis.
