Antibiotics

Question 1

Which penicillin has the best gram negative spectrum?

Answer 1

Ampicilin

Question 2

Role of probenecid in combination with penicillin?

Answer 2

Decreased renal excretion of Penicillin G

Question 3

What causes resistance in MRSA?

Answer 3

Change in Penicillin Binding Proteins

Question 4

Main difference b/w Penicillin G and Penicillin V?

Answer 4

V is more acid stable (hence oral absorption better)

Question 5

Main alternative for patients sensitive to penicillin?

Answer 5

Erythromycin

Question 6

Which patient suffers from Jarisch-Herxheimer reaction after antibiotic prescription?

Answer 6

Syphilis patients given penicillin

Question 7

Drug of choice for treatment of infection involving non-penicillinase producing staph?

Answer 7

Penicillin G

Question 8

Which hypersensitivity is induced by penicillin?

Answer 8

Type B

Question 9

Side effects of Chloramphenicol

Answer 9

Bone-marrow suppression

Question 10

Which antibiotic group works best in basic pH, i.e intestine absorption?

Answer 10

Macrolides

Question 11

Which cephalosporin is not active against anaerobes?

Answer 11

Cefoperazone

Question 12

Mechanism of resistance against chloramphenicol

Answer 12

Inactivation through acetyltransferase enzyme

Question 13

Which antibiotic group causes gray baby syndrome?

Answer 13

Chloramphenicol

Question 14

Which antibiotic is first choice drug in atypical pneumonia by mycoplasma?

Answer 14

Macrolides

Question 15

Which antibiotic group has additional anti-inflammatory and immunomodulatory activities?

Answer 15

Macrolides

Question 16

Which antibiotic group causes fanconi syndrome?

Answer 16

Tetracycline

Question 17

Side effect of Isoniazid?

Answer 17

Peripheral neuritis

Question 18

4 antibiotics effective against atypical mycobacteria?

Answer 18

Rifabutin
Clofazimine
Quinonlones
Clarithromycin

Question 19

What does methotrexate inhibit?

Answer 19

DHFRase (Dihydrofolate Reductase)

Question 20

Aminoglykoside most effective against organism producing aminoglycoside inactivating enzymes?

Answer 20

Amikacin

Question 21

Which type of bacteria is gentamicin effective against?

Answer 21

Oxygen dependent bacteria. Most effective against aerobes

Question 22

Best bactericidal agent in leprosy?

Answer 22

Rifampicin

Question 23

Which nerve is most likely to be damaged after prolonged administration of streptomycin?

Answer 23

Auditory nerve

Question 24

Which antibiotic has a side effect of optic neuritis?

Answer 24

Ethambutol

Question 25

What is first line antitubercular drug?

Answer 25

Isoniazid (INH)

Question 26

Which ABs produce ototoxicity and nephrotoxicity?

Answer 26

Aminoglycosides

Question 27

Orange discoloration in sweat is caused due to?

Answer 27

Rifampicin

Question 28

Most effective drug against extracellular mycobacteria?

Answer 28

Rifampicin