Antibiotics

Question 1

aminoglycosides

Answer 1

Gram- aerobes
Decrease post-junctional acetylcholine receptor sensitivity to acetylcholine, inhibit ACh release pre-synaptically
Potentiate NMB and make reversal more difficult

Question 2

clindamycin

Answer 2

Gram+ cocci, anaerobes
Decreases post-junctional acetylcholine receptor sensitivity to acetylcholine, inhibit ACh release pre-synaptically
If given rapidly, clindamycin has been known to cause sudden cardiac arrest.

Question 3

tetracyclines

Answer 3

broad spectrum antibiotics typically used for specific unusual or environmental acquired infections such as anthrax, brucellosis, Lyme disease, plague, and Rocky Mountain spotted fever
Decrease post-junctional acetylcholine receptor sensitivity to acetylcholine
Phototoxicity and teeth discoloration

Question 4

vancomycin

Answer 4

Gram+
Not known to potentiate NMB
Rapid IV infusions may lead to “red man syndrome” d/t mast cell degranulation and histamine release