Antibiotics

Question 1

Sepsis

Answer 1

co-amox + gentamicin + metronidazole if suspect anaerobic

Question 2

CAP with sepsis

Answer 2

co-amox + clarithromycin + gentamicin if severe

Question 3

CAP without sepsis, CURB-65: 0-1

Answer 3

amoxicillin

Question 4

CAP without sepsis, CURB-65: 2-5

Answer 4

amoxicillin + doxycycline

Question 5

Intra-abdominal sepsis (luminal/biliary)

Answer 5

source control + co-amox + metronidazole if delayed source control/complex abscess

Question 6

CNS infection, assumed bacterial

Answer 6

ceftriaxone + dexamethasone

Question 7

CNS infection, viral features

Answer 7

+ acyclovir (features = obtundation, seizures, confusion)

Question 8

Warfarin levels increase after these Abx

Answer 8

clarithromycin/ciprofloxacin

Question 9

Warfarin levels decrease after this Abx

Answer 9

Rifampicin

Question 10

Abx contraindicated in first trimester

Answer 10

Trimethoprim (neural tube defects)

Question 11

Abx contraindicated at term

Answer 11

nitrofurantoin (neonatal haemolysis)

Question 12

Pseudomonas Abx

Answer 12

Ciprofloxacin (only oral), gentamicin, pip-taz, meropenem, ceftazidime
= when immunosuppressed (neutropenic sepsis)

Question 13

Gentamicin toxicity

Answer 13

nephrotoxic and ototoxic

Question 14

MRSA

Answer 14

vancomycin

Question 15

Extended spectrum β-lactamase infection

Answer 15

carbapenem e.g. meropenem

Question 16

Criteria to diagnose UTI

Answer 16

Positive urinalysis AND symptoms (dysuria, frequency, urgency)

Question 17

UTI + sepsis

Answer 17

co-amoxiclav + single dose gentamicin

Question 18

Catheter associated UTI without symptoms

Answer 18

No treatment

Question 19

Catheter associated UTI with symptoms

Answer 19

co-amoxiclav and catheter change (source control)

Question 20

UTI with upper urinary tract symptoms (pyelonephritis)

Answer 20

co-amoxiclav

Question 21

UTI with prostatitis

Answer 21

Ciprofloxacin (oral) or co-amoxiclav + single dose gentamicin

Question 22

UTI without prostatitis

Answer 22

nitrofurantoin

Question 23

UTI in female

Answer 23

nitrofurantoin

Question 24

Pseudomembranous colitis (diarrhoea after Abx) causative organism

Answer 24

c. diff

Question 25

Necrotising fasciitis

Answer 25

s. aureus | co-amox + clindamycin (+ vancomycin if MRSA)

Question 26

Mild diabetic foot ulcer (or non-diabetic)

Answer 26

flucloxacillin (+ co-trimoxazole if MRSA+)

Question 27

Moderate diabetic foot ulcer

Answer 27

co-amoxiclav

Question 28

Severe diabetic foot ulcer

Answer 28

co-amoxiclav + gentamicin + pip-taz

Question 29

c difficile Abx

Answer 29

metronidazole

Question 30

bronchitis Abx

Answer 30

doxy

Question 31

mild allergy to penicillin - replacement

Answer 31

cephalosporins e.g. cefuroxime

Question 32

lifestyle advice when taking metronidazole

Answer 32

alcohol avoidance - associated with disulfiram like reaction

Question 33

infective exacerbation of COPD

Answer 33

amoxicillin or doxycycline