Antibiotic Quiz Questions Flashcards
Of the following drugs, which are designed specifically to treat traditional S. aureus infections?
Tigecycline
Metronidazole
Nafcillin
Piperacillin
Dicloxacillin
Nafcillin & Dicloxacillin (Methicillin’s are DOC for S. aureus).
Tigecycline has MRSA spectrum (reserve for Methicillin resistance)!
Which of the following drugs are appropriate agents to use against S. pyogenes?
TMX/SMP
Cefadroxil (1st gen CS)
Cefprozil (2nd gen CS)
Ceftazidime (3rd gen CS)
Ciprofloxacin
Cefadroxil & Cefprozil (both cover GAS).
-TMX/SMP has S. pneumoniae coverage but no GAS coverage!
-Ceftazidime reserved for P. aeruginosa… Cipro also best against P. aeruginosa.
Which agents have spectrums of activity against P. aeruginosa?
Cefuroxime Axetil
Ceftazidime
Ceftriaxone
Cefoxitin
Aztreonam
Cefotaxime
Aztreonam & Ceftazidime… Aztreonam = Monobactam w P. aeruginosa coverage & Ceftazidime is 3rd gen CS reserved for P. aeruginosa.
-2nd gens no Pseudomonas coverage (CA & Cefoxitin); Ceftriaxone & Cefotaxime 3rd gens no coverage either.
Of the Carbapenems (Ertapenem, Miropenem, Imipenem), which ones have the best P. aeruginosa coverage?
Miropenem & Imipenem… Ertapenem shitty Pseudomonas coverage!
Jodi recently went on AB treatment for a Staph infection… The prescribed agent did not work due to MRSA presence. What is the most appropriate next-line agent to use?
Vancomycin (DOC for MRSA)
Which of the following agents are indicated for treating Neisseria infections?
Imipenem
Ciprofloxacin
Erythromycin
Ampicillin
Gentamicin
Ciprofloxacin & Ampicillin… All three Fluroquinolones (Cipro / Levo / Moxi) cover Neisseria & Aminopenicillins (Amp / Amoxicillin) cover Neisseria as well.
Which two classes of drugs discussed in class are indicated for Enterobacter species?
4th gen CS & Sulfonamides / Trimethoprim
All of the drug classes discussed that are indicated for P. aeruginosa?
-Ureidopenicillins
-3rd Gen CS (Ceftazidime)
-4th Gen CS
-Carbapenems (Ertapenem bad!)
-Monobactams
-Fluoroquinolones (Cipro best!)
Agents indicated for M. pneumoniae infection?
Macrolides & Tetracyclines
Of the following agents, which are indicated for Chlamydiae species?
Cefepime
Cephalexin
Clarithromycin
Tigecycline
Doxycycline
Clarithromycin (Macro) & Doxycycline (Tetra)
All of the drug classes discussed indicated for Chlamydiae species?
-Macrolides (except Clindamycin)
-Tetracyclines
-Fluoroquinolones
-Sulfonamides / Trimethoprim
What drug(s) is indicated for Non-Beta Lactamase producing E. coli / P. mirabilis / Salmonella?
Amoxicillin & Ampicillin
Niche drug for C. difficile treatment?
Metronidazole
Of the Cephalosporin drugs, which ones are most suitable to treat Staph infections?
4th Gen
-1st / 2nd / 3rd gen no MRSA coverage (even though 1st & 2nd definitely have regular Staph coverage).
What two drugs are indicated for Ampicillin Sensitive E. faecalis & Penicillin Resistant S. pneumoniae?
Ceftaroline & Ceftobiprole… Also indicated for MRSA!
B. pertussis / C. jejuni / H. pylori coverage… What drugs?
Macrolides (Erythromycin / Clarithromycin / Azithromycin)
Which drugs are indicated for Moraxella treatment?
Ciprofloxacin
Tigecycline
Gentamicin
Linezolid
Aztreonam
Azithromycin
Clarithromycin
TMP/SMX
Bottom three… Macrolides & Sulfa’s indicated for Moraxella treatment.
Drug that treats Enterobacter, Citrobacter & Pseudomonas?
Cefepime (4th Gen CS)
Drug that treats GN Rods & Pseudomonas?
Piperacillin (Ureidopenicillin)
Protozoa (ie. Trichomonas) covering agents?
Sulfa’s & Metronidazole
If Vancomycin doesn’t work to treat a MRSA or Enterococcus infection, what is a potential 2nd line agent?
Linezolid (Vancomycin alt.)
Drug class indicated for Rickettsiae & Bartonella infections?
Tetracyclines (Mino / Doxy / Tetracycline)
Two drug classes indicated for Salmonella?
-Aminopenicillins (ie. Ampicillin / Amoxicillin)
-Glycylcyclines (ie. Tigecycline)
What species do Macrolides cover?
-Streptococci
-Pneumococci
-Corynebacteria
-M. pneumoniae
-Chlamydiae sp.
-B. pertussis
-C. jejuni
-H. pylori
Cefepime coverage?
-Enterobacter
-Citrobacter
-P. aeruginosa
Ceftaroline & Ceftobiprole coverage?
-MRSA
-Ampicillin Sensitive E. faecalis
-Penicillin Resistant S. pneumoniae
Penicillin coverage?
-Streptococci
-Meningococci
-Actinomyces
-Anaerobic GP Rods
-Spirochetes
-Clostridia
Aminopenicillin coverage?
-Streptococci
-Enterococci
-Neisseria
-NBLP’s
Monobactams only cover what?
GN Bacilli
Sulfonamides / Trimethoprim coverage?
-Staph (including MRSA)
-S. pneumoniae (NOT GAS!!!)
-S. maltophilia
-Moraxella sp.
-Chlamydiae sp.
-Nocardiae
-Protozoa
-H. influenzae
-Enterobacteriaciae
-Brucella
-P. jirovecii
