Antibiotic Quiz Questions

Question 1

Of the following drugs, which are designed specifically to treat traditional S. aureus infections?

Tigecycline
Metronidazole
Nafcillin
Piperacillin
Dicloxacillin

Answer 1

Nafcillin & Dicloxacillin (Methicillin’s are DOC for S. aureus).

Tigecycline has MRSA spectrum (reserve for Methicillin resistance)!

Question 2

Which of the following drugs are appropriate agents to use against S. pyogenes?

TMX/SMP
Cefadroxil (1st gen CS)
Cefprozil (2nd gen CS)
Ceftazidime (3rd gen CS)
Ciprofloxacin

Answer 2

Cefadroxil & Cefprozil (both cover GAS).

-TMX/SMP has S. pneumoniae coverage but no GAS coverage!

-Ceftazidime reserved for P. aeruginosa… Cipro also best against P. aeruginosa.

Question 3

Which agents have spectrums of activity against P. aeruginosa?

Cefuroxime Axetil
Ceftazidime
Ceftriaxone
Cefoxitin
Aztreonam
Cefotaxime

Answer 3

Aztreonam & Ceftazidime… Aztreonam = Monobactam w P. aeruginosa coverage & Ceftazidime is 3rd gen CS reserved for P. aeruginosa.

-2nd gens no Pseudomonas coverage (CA & Cefoxitin); Ceftriaxone & Cefotaxime 3rd gens no coverage either.

Question 4

Of the Carbapenems (Ertapenem, Miropenem, Imipenem), which ones have the best P. aeruginosa coverage?

Answer 4

Miropenem & Imipenem… Ertapenem shitty Pseudomonas coverage!

Question 5

Jodi recently went on AB treatment for a Staph infection… The prescribed agent did not work due to MRSA presence. What is the most appropriate next-line agent to use?

Answer 5

Vancomycin (DOC for MRSA)

Question 6

Which of the following agents are indicated for treating Neisseria infections?

Imipenem
Ciprofloxacin
Erythromycin
Ampicillin
Gentamicin

Answer 6

Ciprofloxacin & Ampicillin… All three Fluroquinolones (Cipro / Levo / Moxi) cover Neisseria & Aminopenicillins (Amp / Amoxicillin) cover Neisseria as well.

Question 7

Which two classes of drugs discussed in class are indicated for Enterobacter species?

Answer 7

4th gen CS & Sulfonamides / Trimethoprim

Question 8

All of the drug classes discussed that are indicated for P. aeruginosa?

Answer 8

-Ureidopenicillins
-3rd Gen CS (Ceftazidime)
-4th Gen CS
-Carbapenems (Ertapenem bad!)
-Monobactams
-Fluoroquinolones (Cipro best!)

Question 9

Agents indicated for M. pneumoniae infection?

Answer 9

Macrolides & Tetracyclines

Question 10

Of the following agents, which are indicated for Chlamydiae species?

Cefepime
Cephalexin
Clarithromycin
Tigecycline
Doxycycline

Answer 10

Clarithromycin (Macro) & Doxycycline (Tetra)

Question 11

All of the drug classes discussed indicated for Chlamydiae species?

Answer 11

-Macrolides (except Clindamycin)
-Tetracyclines
-Fluoroquinolones
-Sulfonamides / Trimethoprim

Question 12

What drug(s) is indicated for Non-Beta Lactamase producing E. coli / P. mirabilis / Salmonella?

Answer 12

Amoxicillin & Ampicillin

Question 13

Niche drug for C. difficile treatment?

Answer 13

Metronidazole

Question 14

Of the Cephalosporin drugs, which ones are most suitable to treat Staph infections?

Answer 14

4th Gen

-1st / 2nd / 3rd gen no MRSA coverage (even though 1st & 2nd definitely have regular Staph coverage).

Question 15

What two drugs are indicated for Ampicillin Sensitive E. faecalis & Penicillin Resistant S. pneumoniae?

Answer 15

Ceftaroline & Ceftobiprole… Also indicated for MRSA!

Question 16

B. pertussis / C. jejuni / H. pylori coverage… What drugs?

Answer 16

Macrolides (Erythromycin / Clarithromycin / Azithromycin)

Question 17

Which drugs are indicated for Moraxella treatment?

Ciprofloxacin
Tigecycline
Gentamicin
Linezolid
Aztreonam
Azithromycin
Clarithromycin
TMP/SMX

Answer 17

Bottom three… Macrolides & Sulfa’s indicated for Moraxella treatment.

Question 18

Drug that treats Enterobacter, Citrobacter & Pseudomonas?

Answer 18

Cefepime (4th Gen CS)

Question 19

Drug that treats GN Rods & Pseudomonas?

Answer 19

Piperacillin (Ureidopenicillin)

Question 20

Protozoa (ie. Trichomonas) covering agents?

Answer 20

Sulfa’s & Metronidazole

Question 21

If Vancomycin doesn’t work to treat a MRSA or Enterococcus infection, what is a potential 2nd line agent?

Answer 21

Linezolid (Vancomycin alt.)

Question 22

Drug class indicated for Rickettsiae & Bartonella infections?

Answer 22

Tetracyclines (Mino / Doxy / Tetracycline)

Question 23

Two drug classes indicated for Salmonella?

Answer 23

-Aminopenicillins (ie. Ampicillin / Amoxicillin)

-Glycylcyclines (ie. Tigecycline)

Question 24

What species do Macrolides cover?

Answer 24

-Streptococci
-Pneumococci
-Corynebacteria
-M. pneumoniae
-Chlamydiae sp.
-B. pertussis
-C. jejuni
-H. pylori

Question 25

Cefepime coverage?

Answer 25

-Enterobacter
-Citrobacter
-P. aeruginosa

Question 26

Ceftaroline & Ceftobiprole coverage?

Answer 26

-MRSA
-Ampicillin Sensitive E. faecalis
-Penicillin Resistant S. pneumoniae

Question 27

Penicillin coverage?

Answer 27

-Streptococci
-Meningococci
-Actinomyces
-Anaerobic GP Rods
-Spirochetes
-Clostridia

Question 28

Aminopenicillin coverage?

Answer 28

-Streptococci
-Enterococci
-Neisseria
-NBLP’s

Question 29

Monobactams only cover what?

Answer 29

GN Bacilli

Question 30

Sulfonamides / Trimethoprim coverage?

Answer 30

-Staph (including MRSA)
-S. pneumoniae (NOT GAS!!!)
-S. maltophilia
-Moraxella sp.
-Chlamydiae sp.
-Nocardiae
-Protozoa
-H. influenzae
-Enterobacteriaciae
-Brucella
-P. jirovecii