Antibiotic drugs

Question 1

Amino-glycosides

Answer 1

1. ) Bactericidal
2. ) Spectrum: Good against gram negative
3. ) Mechanism: Binds to 30s Ribosome
4. ) Treatment: Tuberculosis

Side effects:
Nephrotoxic: reversible
Ototoxic: Irreversible

Question 2

Chloramphenicol

Answer 2

1. ) Bacteriostatic
2. ) Spectrum: Broad
3. ) Mechanism: Binds to 50s

Side effects:
Dangerous in younger patients who don’t have glucuronly transferase and thus cannot metabolize the drug. This can lead to death

Bone marrow depression occurs with a high dose

Question 3

Erythromycin

Answer 3

1. ) Bactericidal (high dose) or Bacteriostatic (low dose)
2. ) Spectrum: Broad
3. ) Mechanism: Binds to 50s
4. ) Treatment: Good alternative to B- Lactam

Side effects:
Super Infection because it is broad spectrum
Hypersensitivity
hearing impairment

Question 4

Clindamycin

Answer 4

1. ) Bacteriostatic
2. ) Spectrum: Broad
3. ) Mechanism: Binds to 50s
4. ) Treatment: Does not penetrate CNS

Side effects:
Stevens Johnson syndrome (allergic reaction that can be life threatening)

Question 5

Spectinomycin

Answer 5

1. ) Bacteriostatic
2. ) Spectrum: Broad spectrum but mainly used for G-neg
3. ) Mechanism: binds to 30s
4. ) Treatment: Used as alternative to Penicillin

Administered intramuscularly
48h half life