antiarrythmic 2

Question 1

what drug has stronger K+ channels blocker than beta adrenergic receptor antagonist?

Answer 1

sotalol

Question 2

what has the multiple actions on Na, K, Ca channel blockers or alpha, beta receptor antagonist?

Answer 2

amiodarone

Question 3

what is the mech of class IA?

Answer 3

fast Na+ channel blocker

• -> prolongs effective refractory period
• -> prolongs action potential duration

Question 4

what is the alternative drug for chronic treatment of atrial flutter, fibrillation, SVT?

Answer 4

Quinidine

Question 5

what other effects do quinidine have?

Answer 5

1. alpha adrenergic blockade
2. M2 blockade
3. vagal inhibtion

Question 6

what are the toxicities of class IA?

Answer 6

1. diarrhea
2. nausea
3. fever
4. hepatitis
5. thrombocytopenia
6. cinchonism
7. QT prolongation