Angina 2

Question 1

why is dipyridamole used in limit?

Answer 1

b/c it vasodilates coronary arteries which can enhance exercise induced ischemia

Question 2

what is cilostazol?

Answer 2

a quinolinone derivative that inhibits cellular phosphodiesterase

Question 3

what is the mech of cilostazol?

Answer 3

increases cAMP and results in inhibition of platelet aggregation

Question 4

why is lipid lowering agents important to use?

Answer 4

LDL reducing agents decrease the risk of adverse ischemic events in patients with established CAD

Question 5

ACE is also known as

Answer 5

kinase II that is responsible for degrading bradykinin to inactive fragments

Question 6

what are the roles of bradykinin?

Answer 6

1. bradykinin is a vasodilator
2. increases vascular permeability
3. bradykinin can also cause cough and play role in angiodedema
   - -> thus, ACE inhibitors increase bradykinin

Question 7

all ACE inhibitors end with

Answer 7

-pril

Question 8

what are the 4 major side effects of ACE inhibitors?

Answer 8

1. dry cough
2. hypotension
3. hyperkalemia (due to decreased aldosterone)
4. angioedema

Question 9

why are beta-blockers useful?

Answer 9

1. prevent MI and sudden cardiac death as well as reducing angina and ischemia
2. bind to beta-adrenoreceptors blocking the binding of epinephrine and norepinephrine to these receptors
3. stimulation of beta 1 receptors in the heart cause an increase in contractility, heart rate and conduction through the AV node

Question 10

what does beta 2 result in?

Answer 10

beta 2 receptors in vascular smooth muscle result in vasodilation