Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

INDE > Anti Virals > Flashcards

Anti Virals Flashcards

1
Q

Tenofovir

A

Treats: HIV and HBV

MoA: Nuleoside Reverse Transcriptase Inhibitor; requires tri-phosphorylation; Bind RT and incorporates and causes chain termination

Adverse: Lactic Acidosis

Notes: Prodrug available that activates in lymphoid tissues to lower systemic toxicity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Emtricitabine

A

Treats: HIV and HBV

MoA: Nuleoside Reverse Transcriptase Inhibitor; requires tri-phosphorylation; Bind RT and incorporates and causes chain termination

Adverse: Lactic Acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Efavirenz

A

Treats: HIV

MoA: Non-nucleoside reverse transcriptase inhibitor; binds RT and induces lower activity

Adverse: Hepatoxicity, skin rashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Darunavir

A

Treats: HIV

MoA: HIV protease inhibitor via active site binding; prevents processing of polypeptides into mature proteins; produces non-infectious virions

Adverse: Dyslipidemia, insulin resistance, GI effects

Notes: Substrate for Cytochrome P450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ritonavir

A

Treats: HIV

MoA: HIV protease inhibitor via active site binding; prevents processing of polypeptides into mature proteins; produces non-infectious virions

Adverse: Dyslipidemia, insulin resistance, GI effects

Notes: Strong inhibiting substrate for Cytochrome P450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dolutegravir

A

Treats: HIV

MoA: Inhibits HIV integrase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Enfuvirtide

A

Treats: HIV

MoA: Prevents fusion of HIV with cell membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Maraviroc

A

Treats: HIV

MoA: Binds CCR5; blocks interaction with T cells and monocytes

Adverse: Hepatoxicity and systemic allergic reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Oseltamivir

A

Treats: Influenza

MoA: Neurominidase Inhibitor; blocks release of influenza virus from infected cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Paritaprevir

A

Treats: Hep C

MoA: Inhibits Hep C Protease; prevents processing of HCV polyprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ledipasvir

A

Treats: Hep C

MoA: Inhibits Hep C phosphoprotein required for viral RNA sunth and assembly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Ombitasvir

A

Treats: Hep C

MoA: Inhibits Hep C phosphoprotein required for viral RNA sunth and assembly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Sofosbuvir

A

Treats: Hep C

MoA: Inhibits Hep C RNA pol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Acyclovir

A

Treats: Herpes (HSV VZV)

MoA: Blocks viral DNA synth; Inhibits viral pol and incorporates into DNA causing chain termination

Notes: Requires activation via viral Thymidine Kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ganciclovir

A

Treats: Herpes (CMV)

MoA: Blocks viral DNA synth; Inhibits viral pol; NO CHAIN TERMINATION

Adverse: Bone marrow depression

Notes: Requires activation via viral Thymidine Kinase; less selective than acyclovir therefore more toxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Foscarnet

A

Treats: Herpes

MoA: Inhibits viral DNA pol; binds pyrophosphate site of viral enzyme; DOES NOT REQUIRE VIRAL ACTIVATION

Adverse: Nephrotoxicity and hypercalcemia

Notes: Alternative to other herpes meds for resistance and failure

INDE (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions