Anti-virals Flashcards
Acyclovir
Closely related: ganciclovir
Action: blocks viral DNA polymerase
Note: valacyclovir: increased bioavailability
darunavir
Closely related: atazanavir, fosamprenavir, indinavir, lopinavir, saquinavir
Action: HIV protease inhibitor
SE’s: lipodystrophy, insulin resistance
Note: HIV specific
efavirenz
Closely related: nevirapine, delavirdine
Action: non-nucleotide reverse transcriptase inhibitor
SE’s: CNS toxicity, skin rashes
Note: NNRTIs
enfuviritide
Action: viral entryinhibitor
Note: HIV specific
HIV specific drugs
darunavir
enfuviritide
maraviroc
raltegravir
foscarnet
Action: blocks viral DNA synthesis
SE’s: nephrotoxicity
interferon
Action: regulates the Jak-STAT pathway and gene expression
SE’s: bone marrow depression, flu-like symptoms
ledipasvir
Closely related: ombitasvir, elbasvir, daclatasvir
Action: inhibits Hepatitis C NS5A, req. for RNA synthesis
Note: ombitasvir combined with paritaprevir and ritonavir in a single pill (Viekira Pak). HCV specific
maraviroc
Action: binds CCR5 and blocks HIV interaction with T cell and monocyte
Notes: HIV specific
oseltamivir
Related: zanamavir
Action: neuraminidase inhibitor
Note: Influenza specific
paritaprevir
Related: simeprevir, grazoprevir
Action: inhibits Hepatitis C protease
Note:
paritaprevir (part of multi-drug formulation in Viekira Pak) HCV specific
Viekira pack drugs
Treats Hep C: ombitasvir paritaprevir ritonavir dasabovir
raltegravir
Related: dolutegravir, elvitegravir
Action: inhibits HIV integrase
Note: HIV specific
ritonavir
Action: HIV protease inhibitor, also, strong inhibitor of Cyp3A4
Note: boosts levels of other protease inhibitors by inhibiting Cyp3A4 - part of Viekira pack.
sofosbuvir
Related: dasabuvir
Action: Inhibits Hep C RNA polymerase (NS5B)
Note: HCV specific
