Anti-Viral Drugs Flashcards
What kind of viruses are double stranded DNA viruses?
- Herpesvirus
- Pox virus
- Adenovirus
- Hepadnavirus
What makes retroviruses unique?
They are reverse transcribed into DNA and then implimented into the host cell genome (HIV, Human T cell Leukemia Virus)
What drugs block the entry of a virus?
- Viral fusion (T20)
- Host cell co-receptor (maraviroc)
What is the main drug used to treat Hepatitis C?
Ribavirin
Explain a virus’ life cycle step-bystep? (9)
- Recognition
- Attachement
- Penetration
- Uncoating
- 5. Transcription - Protein Synthesis
- Replication
- Assembly / Envelopment
- Lysis / Budding and release
When is aciclovir used?
- Treatment of hepres simplex virus
- Varicella zoster virus
- Shingles
Does not appear to decrease the risk of pain
What are the different methods by which antiviral drugs work?
- Entry inhibitors
- Viral uncoating
- Nucleoside anologue chain termination
- NNRTs
- Protease inhibitors
- Integrase inhibitors
- Virus release inhinitors
- Immunomodulator
Name another herpes virus drug (not aciclovir)
Valaciclovir (better oral availability)
Name 2 entry inhibitors
- T20 (fusion inhibitor)
- Maraviroc (CCR5 antagonist)
What anti-virals tackle viral uncoating?
Amantadine/rimantadine
What anti-virals cause nucleoside anologue chain termination?
Acyclovir and NRTIs (nucleoside reverse transcriptase inhibitors)
How do non-nuceoside reverse transcriptase inhibitors work?
They inhibit reverse transcriptase directly
What are Protease Inhibitors used against?
HIV and HCV encoded protease
Name 2 integrase inhibitors
Raltegravir and Elvitegravir
Name some Virus release inhibitors
Influenza NA inhibitors (Tamiflu and Relenza)
