Anti Ulcer

Question 1

Histamine type 2 blocker

Answer 1

Cimetidine

Famotidine

Nizatidine

Ranitidine

Question 2

Cimetidine interaction

Answer 2

Inhibitors of CYP450 - lots of drug drug interactions

Question 3

H2 for pregnancy

Answer 3

Ranitidine

Question 4

PPIs

Answer 4

Omeprazole

Esomeprazole

Lansoprazole

Dexlansoprazole

Pantoprazole

Raneprazole

Question 5

When to stop PPI

Answer 5

If they get diarrhea- can get c Diff and some have died

Question 6

PPI that has large CYP450 inhibition

Answer 6

Omeprazole

Question 7

PPI for pregos

Answer 7

Lansoprazole

Others too, but not omeprazole!!

Question 8

Sucralfate

Answer 8

Band aid like, sticks to ulcers

Question 9

Misoprostol (EP3 receptor)

Answer 9

Puts prostaglandins in GI to increase blood flow and help ulcers heal

Inhibition towards PP and stimulation of mucous production

Question 10

Pt must be on NSAIDS. What drug do you give for ulcers?

Answer 10

Misoprostol

Question 11

Drug used to kill h pylori as it buries into the tissues

Answer 11

Bismuth +

Metronidazole, tetracycline, clarithtomycin, amoxicillin (antibiotics)

Question 12

H pylori treatment

Answer 12

2 antibiotics +acid reducer (PPI or H2 blocker)

Question 13

Classic triple therapy for h pylori

Answer 13

A PPI, clarithromycin and amoxicillin (or metronidazole if pt had penicillin allergy)

Question 14

Add on therapy for h pylori

Answer 14

Bismuth

Question 15

H pylori with metronidazole resistance give:

Answer 15

Tetracycline

Or consider quadruple therapy with clarithromycin and amoxicillin

Question 16

H pylori with clarithromycin resistance

Answer 16

Sub either amoxicillin or tetracycline