Anti-thyroid Medication

Question 1

Thyroid hormones consists of…?

Answer 1

Triiodothyronine T3 and Tetraiodothyronine T4 /thyroxine/ . These hormones contains 59-65% iodine and calcitonin.

Question 2

Adult daily iodine dose

Answer 2

150mcg /200 mcg pregnancy and lactation and up to 250mcg for children /

Question 3

Thyroxine is absorbed

Answer 3

Best in the duodenum and ileum

Question 4

Lower doses of warfarin required in

Answer 4

Hyperthyroidism and higher doses in hypothyroidism

Question 5

Anti thyroid agents

Answer 5

1. Thioamides /methimazole, propylthiouracil PTU /
2. Iodides / lugol solution and potassium iodide /
3. Adrenoceptor blocking agents /propranolol /

Question 6

Propranolol treat for

Answer 6

Hyperthyroidism, thyroid storm, tachycardia, hypertension, atrial fibrillation /duration 4-6 hours, orally /

Question 7

Propranolol toxicity

Answer 7

Bronchospasm, AV blockade, hypotension, bradycardia

Question 8

Thyroid preparations

Answer 8

1. Levothyroxine T4 /half life 7 days, daily dose 75mcg /
2. Liothyronine T3 /half life 1 days, daily dose 25 mcg /

Question 9

Higher thyroxine adverse effects

Answer 9

Atrophic gastritis, H pylori gastritis, celiac disease, lactose intolerance

Question 10

Thyroxine take time

Answer 10

Empty stomach , 30-60 minutes before meals, 4 hours after meals, or bedtime

Question 11

What is the Myxedema Coma?

Answer 11

End stage of the untreated hypothyroidism. Levothyroxine intravenously 300-400mcg initially.

Question 12

Levothyroxine available as

Answer 12

Euthyrox, levoxyl, novothyrox, tirosint, unithroid

Question 13

Tapazole

Answer 13

Methimazole