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Pharmacology > Anti-depressant Agents > Flashcards

Anti-depressant Agents Flashcards

1
Q

SSRIs

A

Selective serotonin reuptake inhibitors

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2
Q

Approved only for OCD

A

Fluvoxamine

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3
Q

SSRIs six available agents

A

Fluoxetine
Paroxetine
Sertraline
Fluvoxamine
Citalopram
Estitalopram

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4
Q

SSRIs clinical using

A

Major depression, anxiety, panic, OCD, PTSD, perimenopausal vasomotor symptoms, eating disorders /bulimia /

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5
Q

SSRIs toxicity

A

Half life 15-75 hours, orally, cause sexual dysfunction, risk of serotonin syndrome with MAOIs

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6
Q

SNRIs

A

Serotonin Norepinephrine reuptake inhibitors

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7
Q

SNRIs agents

A

Duloxetine
Venlafaxine
Desvenlafaxine
Levomilnacipran
Milnacipran

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8
Q

Three ring structure medication

A

Duloxetine

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9
Q

Bicyclic compounds

A

Venlafaxine and Desvenlafaxine

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10
Q

Approved only for fibromyalgia

A

Milnacipran

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11
Q

Venlafaxine side effects

A

Hypertension

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12
Q

SNRIs toxicity

A

Anticholinergic, sedation, hypertension

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13
Q

TCAs

A

Tricyclic antidepressants

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14
Q

TCAs agents

A

Imipramine
Desipramine
Clomipramine
Trimipramine
Amytriptyline
Nortriptyline
Protriptyline
Doxepin

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15
Q

Only for OCD

A

Clomipramine

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16
Q

TCAs toxicity

A

Anticholinergic, a-blocking effects, sedation, weight gain, arrhythmias, seizures in overdose

17
Q

5-HT receptors modulators

A

Nefazodone
Trazodone

18
Q

Hypnosis for

19
Q

Black box warning hepatoxicity 5-HT receptor ?

A

Nefazodone

20
Q

Vortioxetine

A

Agonists of the 5-HT1A receptor, treat for cognitive dysfunction associated with depression

21
Q

Tetracyclic agents

A

Amoxapine
Maprotiline
Mirtazapine

22
Q

Unicyclic aminoketone

23
Q

Bupropion used for

A

Smoking cessation

24
Q

Mirtazapine used for

25
Q

Lowers seizure threshold effects in

A

Amoxapine and Bupropion

26
Q

Mirtazapine side effects

A

Sedation and weight gain

27
Q

MAOIs

A

Monoamine oxidase inhibitors

28
Q

MAOIs agents

A

Phenelzine
Tranylcypromine
Selegiline

29
Q

Selegiline used for

A

Parkinson disease

30
Q

NMDA receptor antagonists

A

Ketamine
Esketamine

31
Q

To produce prolonged delirium “angel dust ”, drugs of abuse

A

Ketamine / IV route administration /

32
Q

Ketamine used for

A

Anesthesia

33
Q

Esketamine used for

A

Refractory depression, acute suicidal ideation

34
Q

FDA panel voted medication

A

Brexanolone for Postpartum depression

35
Q

Allopregnanolone

A

Brexanolone IV infusion over 60 hours, excessive sedation toxicity

Pharmacology (6 decks)

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