Anti-thrombotic drugs in CVD Flashcards
What drug is a thrombin antagonist?
Dabigatran
What drug class is fondaparinux?
Indirect Xa inhibitor
Which drugs are fibrinolytics?
Alteplase
Tenecteplase
Which drugs are P2Y12 antagonists?
Clopidogrel
Ticagrelor
Prasugrel
Which drug is a 2b3a receptor antagonist?
Abciximab
Mechanism of coronary thrombus?
Is aspirin a reversible or irreversible inhibitor of COX 1?
Irreversible
How is Thromboxane A2 different to Prostacyclin?
Why do we give aspirin high dose in MI?
High dose inhibits both thromboxane A2 and Prostacyclin.
Low dose only inhibits Thromboxane A2.
Why was clopidogrel developed?
To combat acute coronary stent thrombosis
What is clopidogrel resistance?
Which DOAC can cause SOB?
Ticagrelor
When are glycoprotein 2b3a receptor antagonists used?
When is second antiplatelet given for NSTEMI?
After diagnostic angio
What makes thrombosis risk high in mechanical valve?
Older valve type
Mitral>aortic
Poor LV function
AF
Where does warfarin act in the clotting cascade?
1972 was the diSCo era
10
9
7
2
Protein S and C
How is warfarin metabolised?
Liver P450 enzyme group
When is warfarin used?
Warfarin side effects?
Where does heparin act in the clotting cascade?
Antidote for heparin?
Protamine - potent vasodilator
Heparin-induced thrombocytopenia (HIT) mechanism?
Antidote for Dabigatran?
Idarucizumab
Antidote for Rivaroxaban and Apixaban?
Andexanet
How do fibrinolytics work?
When would you give prasugrel/ticagrelor over clopi?
