Anti-Psychotics Flashcards
What atypical antipsychotic drug can cause agranulocytosis?
Clozapine (Atypical, must monitor WBC)
What drugs are most likely to cause weight gain?
Olanzapine and Clozapine (atypicals)
What atypical antipsychotic is most and least likely to cause hyperprolactinemia?
Risperidone- Most
Aripiprazole- Least
What class of drugs is associated with NMS?
Typical antipsychotics (neuroleptics)
What drugs are most likely to cause metabolic side effects?
Clozapine and Olanzapine (atypicals)
Typicals have NO metabolic effects
What drug is most likely to cause acute/chronic extra pyramidal symptoms?
Haloperidol> fluphenazine
What drug is most likely to cause ECG changes as a SE?
Ziprasidone
What other receptors besides D2 do typical antipsychotics act on?
Muscarinic, Histamine (H1) and Alpha adrenergic
What drugs are most likely to cause hypotension?
Chlorpromazine (typical)
Clozapine (atypical)
Both are a1 blockers–> vasodilation–> orthostatic hypotension/syncope
What drug is most likely to cause muscarinic SE?
Clozapine
What is the metabolite of Quetiapine and what additional action does it have?
Norquetiapine- Blocks NE reuptake
What class of antipsychotics does not cause any metabolic effects or stroke?
Typical (neuroleptic) antipsychotics
What drug class would you use to treat extrapyramidal symptoms (EPS/TD) caused by antipsychotics?
Anticholinergic agents (diphenhydramine, etc)
What are EPS?
Dyskinesias (movement disorders) caused by DA blockade –> dystonia, akathisia, pseudoparkinsonism
What are the typical antipsychotics? What SE is much more common then in atypicals?
Chlorpromazine (low potency)
Haloperidol, and Fluphenazine (high potency)
Associated with movement disorders (EPS)
