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Microbiology > Anti-Protozoic/Anti-Helminthics > Flashcards

Anti-Protozoic/Anti-Helminthics Flashcards

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Biology 101 flashcards
1
Q

Metronidazole

A

Anaerobic metabolism, interferes with electron transport and alters DNA
Trade name flagyl
Used for Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis infections

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2
Q

Tinidazole

A

Second generation synthetic nitroimidazole

Used for Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis infections

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3
Q

Chloroquine

A

Erythrocytic cycle (acute malaria)
Mainly active against merozoite of all 4 species
DOC for treatment

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4
Q

Amodiaquine

A

Erythrocytic cycle (acute malaria)
Orally
Mainly active against merozoite of all 4 species

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5
Q

Mefloquine

A 
Erythrocytic cycle (acute malaria)
Most effective as prophylaxis and treatment of acute malaria
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6
Q

Primaquine-Sulfadoxine

A

Exo-erythrocytic cycle (persistent malaria)
Kills liver holdout and prevents recurrence of P. vivax and P. ovale, destroys gametes
Treatment of chloroquine-resistant P. falciparum

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7
Q

Quinocide

A

Exo-erythrocytic cycle (persistent malaria)

Member of same drug family as Primaquine

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8
Q

Prophylaxis

A

Chloroquine
Primaquine- Sulfadoxine
Mefloquine
Tetracycline

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9
Q

Suramin

A

African Sleeping Sickness

NOT effective once organism has crossed CNS

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10
Q

Pentamidine

A

African Sleepiing Sickness

Not as effective as Suramin

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11
Q

Melarsoprol

A

African Sleeping Sickness
Arsenical compound with CNS involvement
Toxic

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12
Q

Nifurtimox and Benzonidaxole

A

Chagas disease
Treatment of acute stage
No treatment against chronic stage

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13
Q

Stibogluconate

A

Leishmaniasis

Arsenic containing compounds

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14
Q

Mebendazole
Thisbendazole
Albendazole

A

Intestinal nematodes

Paralyze roundworms so passed out

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15
Q

Pyrantel Promoate

A

Intestinal nematodes
Paralysis of worms
Alternative agent for Enterobius, Necator and Ascaris

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16
Q

Piperazine

A

Intestinal nematodes

Paralysis of worms

17
Q

Diethylcarbamazine

A

Kills microfilariae

Filariasis

18
Q

Mebendazole

A

Adult worms

Filariasis

19
Q

Praziquantel

A

Broad spectrum against both trematodes and cestodes
Immediate exacerbation of symptoms, schistosomes due to evoking of intense inflammatory response against dead schistosomes

20
Q

Niclosamide

A

Alternative to treating cestodes

Microbiology (5 decks)

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