Anti-parasitics, Pharm

Question 1

enzyme blocked by sulfonamides

Answer 1

dihydropterate synthase (sporozoa)

Question 2

enzyme blocked by nitroimidazoles

Answer 2

pyrubate-ferredoxin oxioreductase (anaerobic protozoa)

Question 3

enzyme blocked by allopurinol riboside

Answer 3

nucleoside phosphotransferase (flagellated protozoa)

Question 4

enzyme blocked by nifurtimox and melarsoprol

Answer 4

trypanothione reductase (kinetoplastida)

Question 5

enzyme blocked by allopurinol

Answer 5

purine phophsoribosyl (protozoa)

Question 6

enzyme blocked by alpha-difluoromethylornithine

Answer 6

ornithine decarboxylase (protozoa)

Question 7

enzyme blocked by glycerol + salicylhydroxamic acid or suramin

Answer 7

glycolytic enzymes (kinetoplastida)

Question 8

enzyme blocked by pyrimethamine and trimethoprim

Answer 8

DHFR (sporozoa)

Question 9

protein blocked by amprolium

Answer 9

thiamin transporter (sporozoa)

Question 10

protein blocked by 4-hydroxyquinolones (atovaquone)

Answer 10

mitochondrial e- transporter

Question 11

protein blocked by benzimidazoles

Answer 11

microtubules

Question 12

enzyme blocked by fluconazole

Answer 12

ergosterol demethylase (kinetoplastida)

Question 13

What is blocked by leamisole, piperaizes, avermectins?

Answer 13

neurotransmitters and muscle contraction