Anti-Lipid meds

Question 1

What are the seven classes of Anti-Lipids?

Answer 1

Statins
Bile acid sequestrants
Fibric acids
Nicotinic acids
Cholesterol absorption inhibitors
"Other"
PCSK9 inhibitor

Question 2

Most potent Statin

Answer 2

Atorvastatin

Question 3

Atorvastatin MOA

Answer 3

Inhibits cholesterol synthesis

Question 4

Indication for Atorvastatin

Answer 4

Hyperlipidemia

Question 5

Side effects of Atorvastatin

Answer 5

Myopathies

Rhabdomyolysis

Question 6

Contraindications for Atorvastatin

Answer 6

Liver Dz (CYP450)

Question 7

Atorvastatin Dx-Dx interaction

Answer 7

Decreases [Dabigitran]

St John’s Wort decrease [Atorvastatin]

Question 8

What do we need to know about Lovastatin?

Answer 8

Caution in GFR

Question 9

What do we need to know about Pravastatin?

Answer 9

Not CYP450 metabolized

Question 10

What do we need to know about Rosuvastatin?

Answer 10

2nd most potent TG/LDL reducer

Question 11

What do we need to now about Simvistatin?

Answer 11

Don’t use the 80mg dose anymore

Question 12

What do we need to know about Fluvastatin?

Answer 12

Daily or BID dosing

Question 13

Cholestyramine - class

Answer 13

Bile acid sequestrant

Question 14

Cholestyramine MOA

Answer 14

Bind bile acids, reducing enterohepatic circulation of cholesterol

Question 15

Indication for Cholestyramine

Answer 15

LDL reduction

Question 16

Side effect of Cholestyramine

Answer 16

Long term use may decrease folic acid absorption

Question 17

Contraindications for Cholestyramine

Answer 17

Bowel or biliary obstruction

Question 18

Cholestyramine PG class

Answer 18

B

Question 19

What does Cholestyramine increase?

Answer 19

Triglycerides

Question 20

What is the other bile acid sequesterant?

Answer 20

Colesevelam

Question 21

Indications for Colesevelam

Answer 21

LDL reduction, esp in DM

Question 22

Colesevelam PG category

Answer 22

C

Question 23

Name the 2 Fibric acid drugs

Answer 23

Gemfibrazil

Fenofibrate

Question 24

Fibric acids MOA

Answer 24

Unknown

Question 25

Indication for Fibric acids

Answer 25

Increased TG

Low HDL

Question 26

Side effects of Fibric acids

Answer 26

N/V/D

gas

Question 27

Contraindication for Fibric acids

Answer 27

Hepatic/renal/gallbladder Dz

Question 28

Fibric acids Dx-Dx interactions

Answer 28

Caution with statins
Avoid Clopidogrel
Potentiates Warfarin

Question 29

Fibric acids’ max impact seen in

Answer 29

3-4 weeks

Question 30

Niacin - drug class

Answer 30

Nicotinic acid

Question 31

Niacin MOA

Answer 31

Inhibits fatty acid secretion from adipose and decreases hepatic triglyceride production

Question 32

Indication for Niacin

Answer 32

Dyslipidemia

Question 33

Side effects of Niacin

Answer 33

Flushing

Gout

Question 34

Contraindications for Niacin

Answer 34

Alcoholism

Peptic ulcer dz

Question 35

Niacin Dx-Dx interactions

Answer 35

May increase [Statin]

Question 36

How do you treat the flushing Niacin produces

Answer 36

Px ASA

Question 37

Zetia - drug class

Answer 37

Cholesterol absorption inhibitor

Question 38

Zetia MOA

Answer 38

Inhibits cholesterol absorption in GI tract

Question 39

Indication for Zetia

Answer 39

Hypercholesterolemia

Question 40

Contraindications for Zetia

Answer 40

Allergy

Liver Dz

Question 41

Zetia Dx-Dx interaction

Answer 41

Fibrates

Question 42

What’s in the “other” category?

Answer 42

Omega 3 Fatty Acids

Question 43

Omega 3 - MOA

Answer 43

Unknown

Question 44

Indication for Omega 3

Answer 44

High TG

Question 45

Omega 3 side effect

Answer 45

Excessive bleeding

Question 46

Omega 3 Dx-Dx interactions

Answer 46

Anticoagulants

Question 47

Evolocumab - drug class

Answer 47

PCSK9 Inhibitor

Question 48

Evolocumab MOA

Answer 48

Monoclonal Ab inhibits LDLR degradation, allowing more LDL to be cleared from the body

Question 49

Indication for Evolocumab

Answer 49

Drug resistant hyperlipidemia

Question 50

How is Evolocumab administered?

Answer 50

SQ injection