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CV 2 meds > Anti-Lipid meds > Flashcards

Anti-Lipid meds Flashcards

1
Q

What are the seven classes of Anti-Lipids?

A 
Statins
Bile acid sequestrants
Fibric acids
Nicotinic acids
Cholesterol absorption inhibitors
"Other"
PCSK9 inhibitor
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2
Q

Most potent Statin

A

Atorvastatin

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3
Q

Atorvastatin MOA

A

Inhibits cholesterol synthesis

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4
Q

Indication for Atorvastatin

A

Hyperlipidemia

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5
Q

Side effects of Atorvastatin

A

Myopathies

Rhabdomyolysis

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6
Q

Contraindications for Atorvastatin

A

Liver Dz (CYP450)

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7
Q

Atorvastatin Dx-Dx interaction

A

Decreases [Dabigitran]

St John’s Wort decrease [Atorvastatin]

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8
Q

What do we need to know about Lovastatin?

A

Caution in GFR

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9
Q

What do we need to know about Pravastatin?

A

Not CYP450 metabolized

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10
Q

What do we need to know about Rosuvastatin?

A

2nd most potent TG/LDL reducer

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11
Q

What do we need to now about Simvistatin?

A

Don’t use the 80mg dose anymore

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12
Q

What do we need to know about Fluvastatin?

A

Daily or BID dosing

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13
Q

Cholestyramine - class

A

Bile acid sequestrant

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14
Q

Cholestyramine MOA

A

Bind bile acids, reducing enterohepatic circulation of cholesterol

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15
Q

Indication for Cholestyramine

A

LDL reduction

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16
Q

Side effect of Cholestyramine

A

Long term use may decrease folic acid absorption

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17
Q

Contraindications for Cholestyramine

A

Bowel or biliary obstruction

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18
Q

Cholestyramine PG class

A

B

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19
Q

What does Cholestyramine increase?

A

Triglycerides

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20
Q

What is the other bile acid sequesterant?

A

Colesevelam

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21
Q

Indications for Colesevelam

A

LDL reduction, esp in DM

22
Q

Colesevelam PG category

A

C

23
Q

Name the 2 Fibric acid drugs

A

Gemfibrazil

Fenofibrate

24
Q

Fibric acids MOA

A

Unknown

25
Q

Indication for Fibric acids

A

Increased TG

Low HDL

26
Q

Side effects of Fibric acids

A

N/V/D

gas

27
Q

Contraindication for Fibric acids

A

Hepatic/renal/gallbladder Dz

28
Q

Fibric acids Dx-Dx interactions

A

Caution with statins
Avoid Clopidogrel
Potentiates Warfarin

29
Q

Fibric acids’ max impact seen in

A

3-4 weeks

30
Q

Niacin - drug class

A

Nicotinic acid

31
Q

Niacin MOA

A

Inhibits fatty acid secretion from adipose and decreases hepatic triglyceride production

32
Q

Indication for Niacin

A

Dyslipidemia

33
Q

Side effects of Niacin

A

Flushing

Gout

34
Q

Contraindications for Niacin

A

Alcoholism

Peptic ulcer dz

35
Q

Niacin Dx-Dx interactions

A

May increase [Statin]

36
Q

How do you treat the flushing Niacin produces

A

Px ASA

37
Q

Zetia - drug class

A

Cholesterol absorption inhibitor

38
Q

Zetia MOA

A

Inhibits cholesterol absorption in GI tract

39
Q

Indication for Zetia

A

Hypercholesterolemia

40
Q

Contraindications for Zetia

A

Allergy

Liver Dz

41
Q

Zetia Dx-Dx interaction

A

Fibrates

42
Q

What’s in the “other” category?

A

Omega 3 Fatty Acids

43
Q

Omega 3 - MOA

A

Unknown

44
Q

Indication for Omega 3

A

High TG

45
Q

Omega 3 side effect

A

Excessive bleeding

46
Q

Omega 3 Dx-Dx interactions

A

Anticoagulants

47
Q

Evolocumab - drug class

A

PCSK9 Inhibitor

48
Q

Evolocumab MOA

A

Monoclonal Ab inhibits LDLR degradation, allowing more LDL to be cleared from the body

49
Q

Indication for Evolocumab

A

Drug resistant hyperlipidemia

50
Q

How is Evolocumab administered?

A

SQ injection

CV 2 meds (3 decks)

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