Anti-Inflammatory Meds Flashcards
Prototype salicylate
Inhibits cox 1 & 2
Adverse effects: GI irritation, bleeding, salicilism
Not for kids. Leads to Reye’s
Not for renal patients (blocking cox 1 dcrs blood to kidneys
Aspirin (AS A)
Drug class that inhibits cox 1 & 2 Anti-Inflammatory, analgesic, antipyretic, antiplatelet Prototype:aspirin
Salicylates
Aspirin toxicity
Sx: HA, tinnitus, GI distress, drowsy, confused
Result of long term therapy or OD
Salicilism
Antipyretic, analgesic Analgesic mechanism unknown Safe for kids. Few adverse effects: hepatotoxicity, renal toxicity Antidote Mucamyst 4g/day max
Acetaminophen
NSAID class that blocks cox 1 & 2
1st gen
NSAID that blocks only cox 2
2nd gen
Anti-Inflammatory, antipyretic, analgesic
Adv effects: GI upset, kidney probs, HTN, dyspnea, bronchospasm, clotting issues
Contraindications: peptic ulcers, heart disease
Broken into 3 categories based on derivative
NSAIDS first gen
Advil, naproxen, indomethacin, diclofenac, meloxicam
2nd gen NSAID prototype Acts on cox 2 only Used for arthritis Adv effects: HA, dizzy, sleep disturb HTN, risk of CVA or MI Less GI effects than 1st gen
Celecobix (Celebrex)
Unlike other NSAIDs
2 types: neurotic agent & uricosuric
Treat build-up of uric acid
Anti gout meds
Mitotic agent inhibits WBC integration into tissues with uric acid crystals
Adv effects: drowsy, dizzy, HA, marrow depression, NVD, abd pain
Push fluids
Colchicine (Colcryx)
Uricosuric agent that inhibits the enzyme that converts purines, which come from food, into uric acid
Dosage decreases based on creatinine
Allopurinol (zyloprim)
Things controlled by cox 1
Blood to kidneys
Enhance platelet aggregation
Dcrs gastric acid, incrs bicarb
Thing controlled by cox 2
Inflammation
