Anti-inflammatory (CH 12)

Question 1

How do NSAIDS work?

Answer 1

stop the activation of the arachidonic acid pathway; reduce pain by blocking prostaglandins

Question 2

Antipyretics

Answer 2

Inhibit prostaglandin E2 in the brain

Question 3

Inflammation Relief

Answer 3

inhibits wither the leukotriene pathway or the prostaglandin pathway

Question 4

Ibuprofen

Answer 4

Motrin, Advil

Question 5

Ketoprofen

Answer 5

Orudis

Question 6

Ketorolac

Answer 6

Toradol

Question 7

Naproxen

Answer 7

Naprosyn

Question 8

Adverse Effects

Answer 8

dyspepsia (difficulty digesting), heartburn, epigastric distress, nausea, GI bleeds, mucosal lesions

Question 9

2nd Generation NSAIDS

Answer 9

Called COX-2 inhibitors, more specific in their action, reduces GI distress

Question 10

2nd Gen Adverse Effects

Answer 10

cardiac arrhythmias, MI, stroke

Question 11

Nursing Precautions

Answer 11

Don’t give to pt with: stomach ulcer/bleed, asthma, allergy to aspirin or sulfa, kidney/liver problems, pregnant

Question 12

What labs does the nurse get before giving NSAIDS?

Answer 12

CBC, platelet count, cardiac, renal and liver

Question 13

NSAID Drug interactions

Answer 13

alcohol, heparin and warfarin, phenytoin, steroids, and sulfonamides

Question 14

Salicylates

Answer 14

Give with food/milk, give to pts 12 and older

Question 15

BP and NSAIDS

Answer 15

monitor pt BP because NSAIDS can cause new-onset hypertension and aggrevate previous hypertension (especially for pts also on diuretics)