Anti-Inflammatory Agents

Question 1

Inflammatory Cascade

Inflammatory Stimulus => ____________separated from the membrane by _____________=> ________________________ metabolizes AA to the prostaglandin_____________ => converted to specific prostaglandins by tissue-specific enzymes

Answer 1

Inflammatory Stimulus => Arachidonic Acid (AA) separated from the membrane by Phospholipase A2. => Cyclooxygenase (COX) metabolizes AA to the prostaglandin H2(PGH2) => converted to specific prostaglandins by tissue-specific enzymes

Question 2

COX 1 vs. COX2

Adverse effects of each?

Answer 2

Question 3

Role of Thromboxane A2 (TXA2)?

Effect of its Inhibition?

Answer 3

Question 4

Role of Prostacyclin (PGL2)?

Effect of its Inhibition?

Answer 4

Question 5

Role of Prostaglandin E2 (PGE2)?

Effect of its Inhibition?

Answer 5

Question 6

Role of Prostaglandins Prostaglandins I2, A2 & E2?

Effect of their Inhibition?

Answer 6

Question 7

Analgesic vs. Antiinflamatory effects of NSAIDs?

Answer 7

Analgesic effects: start after first dose, full effect within 1 week

Anti-Inflammatory Effects: Full effect takes up to 3 weeks

Question 8

Classification of NSAIDs by COX1/COX2 Inhibtion?

Answer 8

Question 9

Selective inhibition of COX-2 is associated with less __________

Answer 9

Selective inhibition of COX-2 is associated with less GI intolerance

Question 10

___________ and _____________: Relatively COX-1 Selective NSAIDs

_____________: Relatively COX-2 Selective (Similar to __________ (selective COX2 Inhibitor))

Answer 10

Indomethacin and Naproxen: Relatively COX-1 Selective NSAIDs

Diclofenac: Relatively COX-2 Selective (Similar to Celecoxib (selective COX2 Inhibitor))

Question 11

Indications for NSAIDs?

Answer 11

Question 12

NSAID Pharmacokinetics?

Answer 12

Question 13

Common NSAID Interactions and their Side Effects?

Answer 13

Question 14

NSAID Hypersensitivity Reactions?

Answer 14

Question 15

NSAIDs and GI Toxicity

• Risk Factors?
• Indications for co-prescribing PPI?
• Prescribing Recommendations?

Answer 15

Question 16

NSAIDs and Cardiovascular Risk?

• MOA?
• Prescribing Recommendations?

Answer 16

Question 17

NSAIDs and Nephrotoxicity?

• MOA?
• Prescribing Recommendations?

Answer 17

Question 18

NSAIDs and Asthma?

Answer 18

Question 19

NSAIDs and Alcohol?

Answer 19

Question 20

NSAIDs and Pregnancy?

Answer 20