Anti-Infectives 3 Flashcards
Clindamycin covers what?
Gram positive
Anaerobic
Special use of clindamycin?
Topical acne cream
Can you use Clindamycin for enterococcal infections?
No
Who uses Clindamycin? Why?
Dentists
Excellent abscess penetration
What drug has the highest incidence of C. diff?
Clindamycin
Is clindamycin expensive or cheap?
Expensive
Mupirocin covers what?
Gram positive organisms that cover skin infections
What are some diseases mupirocin is good for?
Folliculitis, impetigo, nasal staphi
How does Mupirocin come?
Topically
What is a special use of Mupirocin?
recurrent MRSA infections
Linezolid is treatment for what?
MRSA or VRE serious infections
What is the bioavailiability of Linezolid?
EXCELLENT (whereas vancomycin is not)
What is the a/e of linezolid?
Thrombocytopenia (worry under 100k)
Linezolid is a what?
Reversible, non-selective MAO-I so avoid SSRI therapy
What does MAO do?
Chew up NTs (dopamine, serotonin, epi)
Why is Linezolid so special?
Oral, at home option for MRSA
If risk of sepsis or serious MRSA infection, what do you give?
IV Vancomycin
What is St. Johns Wart?
herbal mood elevator (SSRI) OTC
What drugs cause ototoxicity?
NSAID
Furosemide (if pushed too quickly)
Aminoglycoside
Aminoglycosides cover what?
Gram negative (including PA) Enterococcus
How is aminoglycoside administered?
With another drug for PA infections
Aminoglycoside is only available how?
Parentally (IV)
NOT absorbed orally
What is the example of Aminoglycoside?
Gentamicin & Neomycin
What are the 2 a/e of aminoglycosides?
Nephotoxic
Ototoxic
