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Pharmacology 4 > Anti-Infectives 3 > Flashcards

Anti-Infectives 3 Flashcards

1
Q

Clindamycin covers what?

A

Gram positive

Anaerobic

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2
Q

Special use of clindamycin?

A

Topical acne cream

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3
Q

Can you use Clindamycin for enterococcal infections?

A

No

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4
Q

Who uses Clindamycin? Why?

A

Dentists

Excellent abscess penetration

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5
Q

What drug has the highest incidence of C. diff?

A

Clindamycin

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6
Q

Is clindamycin expensive or cheap?

A

Expensive

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7
Q

Mupirocin covers what?

A

Gram positive organisms that cover skin infections

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8
Q

What are some diseases mupirocin is good for?

A

Folliculitis, impetigo, nasal staphi

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9
Q

How does Mupirocin come?

A

Topically

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10
Q

What is a special use of Mupirocin?

A

recurrent MRSA infections

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11
Q

Linezolid is treatment for what?

A

MRSA or VRE serious infections

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12
Q

What is the bioavailiability of Linezolid?

A

EXCELLENT (whereas vancomycin is not)

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13
Q

What is the a/e of linezolid?

A

Thrombocytopenia (worry under 100k)

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14
Q

Linezolid is a what?

A

Reversible, non-selective MAO-I so avoid SSRI therapy

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15
Q

What does MAO do?

A

Chew up NTs (dopamine, serotonin, epi)

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16
Q

Why is Linezolid so special?

A

Oral, at home option for MRSA

17
Q

If risk of sepsis or serious MRSA infection, what do you give?

A

IV Vancomycin

18
Q

What is St. Johns Wart?

A

herbal mood elevator (SSRI) OTC

19
Q

What drugs cause ototoxicity?

A

NSAID
Furosemide (if pushed too quickly)
Aminoglycoside

20
Q

Aminoglycosides cover what?

A 
Gram negative (including PA) 
Enterococcus
21
Q

How is aminoglycoside administered?

A

With another drug for PA infections

22
Q

Aminoglycoside is only available how?

A

Parentally (IV)

NOT absorbed orally

23
Q

What is the example of Aminoglycoside?

A

Gentamicin & Neomycin

24
Q

What are the 2 a/e of aminoglycosides?

A

Nephotoxic

Ototoxic

25
Q

How do you treat hepatic encephalopathy?

A

Neomycin PO to decontaminate the colon and less ammonia builds up

26
Q

QIDP cover what?

A

gram positive00 including MSSA and MRSA

27
Q

QIDP are used to treat what?

A

acute bacterial skin and skin structure infections

28
Q

Ammonia mimics what?

A

GABA

29
Q

What is urea?

A

2 ammonias + ketone

30
Q

Nitazoxanide is used for what?

A

Anti-protozoal such as travelers diarrhea

31
Q

Rifaximin is used for what?

A

diarrhea, usually e. coli, possibly C. jejune, Shigella, and Salmonella

32
Q

Is Rifaximin absorbed well?

A

No, only for GI with no systemic therapy

33
Q

Whats another use for rifaximin?

A

Hepatic encephalopathy

34
Q

What drugs cause pulmonary fibrosis?

A

Nitrofurantoin

Amiodarone

35
Q

Nitrofurantoin common treatment of what?

A

UTI

Pharmacology 4 (4 decks)

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