Anti-fungals

Question 1

Name the 5 types of antifungals and give one example of each.

Answer 1

Fluorinated pyrimidine analogues (5-flucytosine). Polyenes(nystatin).
Allylamines and thiocarbamates (Terbinafin).
Azoles and triazoles (micon-, flucon-,itracon-,posacon-, vorcon-, ravucon-).
Echinocandins (caspofungin, micafungin, anidulafungin).

Question 2

Mode of action for Fluorinated pyrimidine analogues.

Answer 2

RNA/DNA biosynthesis (misincorporation of 5-fluorouridine).

Question 3

Mode of action for polyenes

Answer 3

Cell membrane ergosterol (increased permeability of membrane).

Question 4

Mode of action for allylamine and thiocarbamates.

Answer 4

Inhibition of ergosterol biosynthesis.

Question 5

Mode of action for azoles and triazoles

Answer 5

Inhibition of ergosterol biosynthesis and accumulation of toxic sterol intermediates.

Question 6

Mode of action for Echinocandins

Answer 6

Inhibition of 1,3 β-D-glucan biosynthesis