Anti fungal Drugs (Superficial Mycoses) Flashcards
In regards to superficial mycoses, there are two groups of infections: _____ species infect mucus membranes; _____ infect skin, hair, and nails
Candida; Dermatophytes
What are the 4 drugs used for superficial mycoses?
Azoles, Griseofulvin, Polyene antibiotics, Allyamines
What are the adverse effects of Topical clotrimazole?
skin application: stinging, erythema, edema
intravaginal application: burning, cramps
Griseofulvin is active against superficial ____ infections and inactive against _____ infections
dermatophytic; candidiasis
What is the MOA of Griseofulvin?
deposited in keratin of skin, hair, and nails - inhibits fungal mitosis by binding microtubules
How is Griseofulvin administered?
orally
Nystatin is a Polyene antibiotic. What is its clinical use?
topical treatment for candidiasis of skin, mucous membranes, vulvovaginal region
What is the MOA of Nystatin?
similar to amphotericin B - binds ergosterol
How is Nystatin administered?
oral and topical
note: excretes in feces following oral administration
Nystatin is too toxic if administered by ____ ____
parenteral injections
Naftifine is an Allyamine. What is its clinical use?
dermatophyte infections
What is the MOA of Naftifine?
inhibits enzyme squalene epoxidase
What is the clinical use of Ciclopirox?
broad spectrum skin and nail infections
What is the MOA of Ciclopirox?
chelates iron and aluminum (there are metal dependent fungal enzymes that protect fungi from peroxides)
Which drug is preferred when treating Candidiasis in a patient with moderate to severe illness or who have had an azole recently? What about patients who have a less serious case and have not had an azole treatment recently?
Caspofungin; Fluconazole
