anti-fungal drugs Flashcards

1
Q

What two categories are fungi subdivided into?

A

Yeasts or moulds (filamentous fungi)

can be both

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2
Q

What are the four classes of antifungals?

A

Polyenes, Azoles, Allylamines, Echinocandins

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3
Q

What do polyenes bind to in the fungal cell wall resulting in increased permeability?

A

ergosterol

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4
Q

polyene
IV use
serious systematic fungal infection
extremely toxic

A

Amphotericin B

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5
Q

polyene

topical use only (creams for fungal skin infections, pessaries for vaginal candida infections, oral suspension)

A

Nystatin

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6
Q

What is fluconazole used to treat?

A

yeast infection

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7
Q

Voriconazole and itraconazole are azole antifungal drugs used to treat what?

A

Aspergillosis

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8
Q

How do the azoles and allylamines work?

A

they suppress ergosterol synthesis (they each act at a different stage of the pathway however)

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9
Q

What is Terbinafine used for?

A

Fungal infection of skin and nails

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10
Q

How to Echinocandins work?

A

They inhibit the synthesis of glucan polysaccharide

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11
Q

Caspofungin, Mycafungin and Anidulafungin are members of which class of antifungal drugs?

A

Echinocandins

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12
Q

What are Echinocandins used for?

A

Serious Candida and Aspergillus infections

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