Anti-coagulation Flashcards
MOA UFH
1) potentiates antithrombin 3–> inhibit fibrinogen to fibrin
2) indirectly inactivates 2a (thrombin)
Bolus and maintenance of UFH
Bolus 80U/kg
Maintenance 12U/kg/hr
UFH and pregnancy
Does not cross placenta
Indication UFH
thrombosis, PE, DVT (prophylaxis and tx of both), coagulopathies, ACS
Monitor UFH
PTT; titrate PTT 1.5-2x normal value
S/E UFH
hemorrhage, hyperkalemia, HIT
Caution UFH
severe thrombocytopenia
Safer in kidney disease LMWH or UFH?
UFH
Antidote UFH
protamine sulfate
MOA LMWH
1) inactivates Xa more than UFH
2) potentiate antithrombin 3
3) inhibit less thrombin
Indication LMWH
thrombosis, PE, coagulopathies, DVT, clot prevention, ACS
Monitor LMWH
none
Half life LMWH
12h
S/E LMWH
hemorrhage, anemia, thrombocytopenia (less than UFH)
Caution LMWH
elderly and renal disease
Antidote LMWH
None
MOA thrombin inhibitor
inhibit thrombin directly
Indication dabigatron
DVT, PE, Afib, prevent thromboembolism
Indication argatroban
TOC HIT
Indication bivalirudin
antigoag for CI, tx HIT
S/E thrombin inhibitor
bleed, dyspepsia, abdominal pain, increase LFT
Caution thrombin inhibitor
acute bleeding, renal dosing
Antidote thrombin inhibitor
None
MOA factor X inhibitors
synthetic selectiveXa inhibitor; selectively binds to AT3
