Anti-arrhythmic Flashcards
Class 1
Sodium channel blocks
MOA class 1a
1) decrease conduction velocity and prolong repolarization
2) prolong AP
3) increase excitation threshold
Indication Class1a
atrial and ventricular arrhythmia
S/E Class1a
Torsades, hypotension, tachycardia, tinnitus
Caution class1a
renal disease
MOA class1b
1) decrease conduction velocity and shorten repolarization
Indication class 1b
stable VT
C/I Class 1B
narrow complex SVT
MOA Class 1C
1) decrease conduction velocity and increase QRS prolongation
Indication Class1C
ventricular tachycardia
Class 2
BB
MOA class 2
slow SA and AV node conduction via SNS blockade
Indication Class 2
a. flutter, a. fib, PSVT, PVC
S/E Class 2
bradycardia, hypotension, fatigue, sexual dysfunction
C/I class 2
sinus bradycardia, 2nd/3rd heart block, shock
Class 3
potassium channel blocker
MOA class 3
potassium channel blocker–> AP prolong and prolong refractory period; increase QT length
Special about Amiodarone
characteristics of class 1-4
Indication class 3
atrial and ventricular arrhythmia; refractory SVT
S/E class 3
corneal deposits over 6mo use, pulmonary fibrosis, thyroid disease, blue/green skin discoloration, increase LFT, hypotension
Class 4
CCB
MOA class 4
slow SA and AV node
Indication class 4
a. flutter, a. fib, PSVT
S/E class 4
constipation and peripheral edema
