Anti-cholesterol drugs Flashcards
Give two examples of statins
Simvastatin and atorvastatin
What do statins block
HMG CoA reductase
What effect does blocking the HMG CoA reductase have
Reduced LDL production in liver and increased clearance of LDL in the liver
What four pathological effects do statins have
Decrease inflammation, reverse endothelial dysfunction, decrease thrombosis and stabilize atherosclerotic plaques
Which 6 disease/scenarios are statins used
Hypercholesterolaemia, diabetes, angina, MI, TIA and high risk of CVA
Why are statins not used in pregnancy
Cholesterol is needed for foetal development
2 side effects of statins
Myopathy and rhabdomyolysis renal failure
2 examples of fibrates
Bezafibrate and gemfibrozil
What effect do fibrates have
Decrease triglyceride levels and slight decrease in LDL and HDL by decreasing liver’s production of the particle carrying them in the blood
When are fibrates used
Hypertriglyceridaemia and low HDL cholesterol
Side effects in fibrates
May cause myotosis and therefore adviced to use along with statins
Examples of bile acid binding resins
colestryamine, colestipol and colsevelam (The cols)
What do bile acid binding resins do
Cause the excretion of bile salts, resulting in more cholesterol to be converted to bile salts. This decreases absorption of triglycerided and increased LDL receptor expression (causing increased clearance of LDL)
Side effects of bile acid binding resins
G.I. tract infections
