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PHARMACOLOGY 3.0 > Anti Cancer Drugs > Flashcards

Anti Cancer Drugs Flashcards

(82 cards)

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1
Q

Chlorambucil

A

Nitrogen Mustards

(Chronic Lymphocytic Leukemia)

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2
Q

Cyclophosphamide

A

Nitrogen mustards

(Lymphocytic Leukemia)

[Hemorrhagic Cystitis]

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3
Q

Ifosfamide

A

Nitrogen mustards

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4
Q

Mechlorethamine

A

Nitrogen mustards

(Hodgkin’s disease)

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5
Q

Melphalan

A

Nitrogen mustards

(Malignant melanoma, Mutliple myeloma)

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6
Q

Altretamine

A

Ethylenemelamine Derivatives

(Ovarian CA)

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7
Q

Thiotepa

A

Ethylenemelamine Derivatives

(Breast and Ovarian CA)

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8
Q

Busulfan

A

Alkyl Sulfonate

(Chronic Myelogenous Leukemia)

[Interstitial Pneumonitis, Pulmonary fibrosis]

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9
Q

Decarbazine

A

Triazenes

(Melanoma, Hodgkin’s)

[CNS depression]

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10
Q

Procarbazine

A

Triazenes

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11
Q

Temozalamide

A

Triazenes

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12
Q

Cisplatin

A

Platinum analogs

(non Hodgkin’s Lymphoma)

[Ototoxicity, Nephrotoxicity, Peripherla Sensory Neuropathy]

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13
Q

Carboplatin

A

Platinum analogs

[irreversible Nephrotoxicity]

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14
Q

Oxaloplatin

A

Platinum analogs

administered Intrvenously

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15
Q

Carmustine

A

Nitrosoureas

(Brain tumors)

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16
Q

Lomustine

A

Nitrosoureas

(Brain tumors)

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17
Q

Semustine

A

Nitrosoureas

(Brain tumors)

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18
Q

Streptozocin

A

Nitrosoureas

[low Bone marrow toxicity]

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19
Q

Methotrexate

A

Antifolate

(Acute lymphocytic leukemia)

[Megaloblastic Anemia]

Has oral and IV preparation

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20
Q

Pemetrexed

A

Anti-folate

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21
Q

5-Flourouracil

A

Pyrimidine Analogs

(Breast, Colorectal CA)

[Megaloblastic anemia]

Linear dose-response curve

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22
Q

Capecitabine

A

Pyrimidine analogs

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23
Q

Azacitidine

A

Pyrimidine analogs

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24
Q

Cytarabine

A

Deoxycytidine Analogs

(AML, CML, ALL, CLL)

[Megaloblastic Anema, Neurotoxicity]

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25
Gemcitabine
Pyrimidine Analogs | (Pancreatic, Bladder, Breast CA)
26
Fludarabine
Purine Antagonists
27
Cladribine
Purine Antagonists | (Hairy cell Leukemia)
28
6-Thiopurine
Purine Antagonists | (Childhood Acute Leukemia)
29
Mercaptopurine
Purine Antagonists (Childhood Acute Leukemia) has oral and IV preparation
30
Thioguanine
Purine Antagonists
31
Vincristine
Vinca Alkaloid (Germ cell tumor, Kaposi's Sarcoma) [Neurotoxic, Areflexia]
32
Vinblastine
Vinca Alkaloids (Rhabdomyosarcoma, Neuroblastoma, Wilm's tumor, Acute Lymphocytic Leukemia) [Neurotoxic, Areflexia]
33
Vinorelbine
Vinca Alkaloid (non small cell lung CA) [Neurotoxic, Areflexia]
34
Paclitaxel
Taxanes [Myalgia, Arthralgia]
35
Docetaxel
Taxanes
36
Etoposide
Epipodophyllotoxins (small and non-small cell Lung CA) [Diarrhea] Oral or IV
37
Tenoposide
Epipodophyllotoxins (Acute Lymphocytic Leukemia) [Diarrhea] IV only
38
Topotecan
Camptothecins (Breast and Lung CA) renal excretion
39
Irinotecan
Camptothecins (Colorectal CA) Bile and feces excretion
40
Doxorubicin
Anthracycline [Cardiotoxic]
41
Antracyclines
MOA: ## Footnote 1. Topoisomerase II dependent DNA cleavage 2. Generation of free radicals 3. Intercalate with DNA double helix - Doxorubicin, Daunorobucin, Idarubicin, Epirubicin, Mitoxantrone ADR: Vesicant
42
Daunorobucin
Anthracyclines [Cardiotoxic]
43
Idarubicin
Anthracycline
44
Epirubicin
Anthracycline
45
Mitoxantrone
Anthracycline [Blue discoloration of the fingernails and urine]
46
Dactinomycin
Non-Anthracycline Anticancer Antibiotic MOA: same as Anthracyclines [Vesicant]
47
Plicamycin
Non-Anthracycline Anticancer Antibiotic MOA: complex with Mg & DNA; Blocks RNA synthesis [Hepatotoxic]
48
Mitomycin
Non-Anthracycline Anticancer Antibiotic MOA: crosslinks between complementary strands of DNA --\> impair replication [HUS, Thrombocytopenia, Interstitial Pneumonitis]
49
Bleomycin
Non-Anthracycline Anticancer Antibiotic cell cycle specific (only) MOA: DNA strand scission by interacting with O2 and Fe [Pulmonary Fibrosis]
50
Fluoxymesterone
Androgen [Cholestatic jaundice]
51
Flutamide
Androgen Antagonist (Prostatic CA) [Hot flushes, decreased libido, Impotence]
52
Cyprotenone
Androgen Antagonist
53
Firastemide
Androgen Antagonist
54
Diethylstilbestrol
Estrogen
55
Ethinylestradiol
Estrogen
56
Tamoxifen
Estrogen Antagonist (Breast CA) [Hot flushes, osteoporosis]
57
Hydroxycortisone Prednisone
Corticosteroids [Immunosuppression]
58
Anastrozole
Aromatase Inhibitor (Advanced ER/PR (+) Tamoxifen resistant Breast CA) [Myelosuppression]
59
Letrozole
Aromatase inhibitor [Myelosuppression]
60
Aminoglutethimide
Aromatse Inhibitor [Myelosuppression]
61
Leoprolide
Gonadotropin releasing Hormone | (Metastatic Prostatic CA)
62
Goserelin
Gonadotropin Releasing Hormone
63
Octreotide
Peptide Hormone (GI cancer) [Bradycardia]
64
Growth Signal Reductors | (TAFT)
* Tamoxifen * Aromatase Inhibitors * Fluvestrant * Toremefene
65
Tyrosine Kinase Inhibitors (DIN) "-nib"
* Dasatanib * Imatinib * Nilotinib
66
Her2 Inhibitors
* Lapatinib * Trastuzumab
67
EGRF Inhibitors
* Panitumumab (Humanized) * Cetuximab (Chimeric)
68
mTOR kinase Inhibitors
* Temsirolimus * Everolimus
69
Histone Deacetylases
* Vorinostat * Romidespin
70
Retinoid Receptors (BAT) as in paniki
* Bexarotene * Alitretinoin * Tretinoin
71
Bortezonib
Proteasome Apoptosis Inducer
72
Pralatrexate
RFC-1 Apoptosis Inducer
73
VEGF inhibitors (Anti Angiogenesis)
* Bevacizumab * Sunitinib * Sorafenib
74
Treatment for the Adverse Drug reaction of Cisplatin
Amifostine
75
Treatment for Metastatic Breast CA
Trastuzumab
76
Drug Combination for Cervical CA
Cisplatin/Carboplatin + 5-Flourouracil
77
Drug combination for Colon CA (3) * FOLFOX * FOLFIRI * CapeOx
* FOLFIRI: * 5-FU + Leucovorin + Irinotecan/Topotecan * FOLFOX: * 5-FU + Leucovorin + Oxaliplatin * CapeOx * Capecitabine + Oxaliplatin
78
Drug combination for ALL
* Vincristine + Predisone (remission) * 6-Mercaptopurine + Methotrexate + Cyclophosphamide (Maintenance)
79
Drug combination for AML
* Cytarabine + Doxorubicin
80
Drug Combination for CLL
Chlorambucil + Prednisone
81
Drug used for Treatment of CML
Busulfan
82

PHARMACOLOGY 3.0 (5 decks)

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