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PHARMACOLOGY 3.0 > Anti Cancer Drugs > Flashcards

Anti Cancer Drugs Flashcards

1
Q

Chlorambucil

A

Nitrogen Mustards

(Chronic Lymphocytic Leukemia)

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2
Q

Cyclophosphamide

A

Nitrogen mustards

(Lymphocytic Leukemia)

[Hemorrhagic Cystitis]

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3
Q

Ifosfamide

A

Nitrogen mustards

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4
Q

Mechlorethamine

A

Nitrogen mustards

(Hodgkin’s disease)

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5
Q

Melphalan

A

Nitrogen mustards

(Malignant melanoma, Mutliple myeloma)

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6
Q

Altretamine

A

Ethylenemelamine Derivatives

(Ovarian CA)

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7
Q

Thiotepa

A

Ethylenemelamine Derivatives

(Breast and Ovarian CA)

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8
Q

Busulfan

A

Alkyl Sulfonate

(Chronic Myelogenous Leukemia)

[Interstitial Pneumonitis, Pulmonary fibrosis]

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9
Q

Decarbazine

A

Triazenes

(Melanoma, Hodgkin’s)

[CNS depression]

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10
Q

Procarbazine

A

Triazenes

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11
Q

Temozalamide

A

Triazenes

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12
Q

Cisplatin

A

Platinum analogs

(non Hodgkin’s Lymphoma)

[Ototoxicity, Nephrotoxicity, Peripherla Sensory Neuropathy]

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13
Q

Carboplatin

A

Platinum analogs

[irreversible Nephrotoxicity]

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14
Q

Oxaloplatin

A

Platinum analogs

administered Intrvenously

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15
Q

Carmustine

A

Nitrosoureas

(Brain tumors)

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16
Q

Lomustine

A

Nitrosoureas

(Brain tumors)

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17
Q

Semustine

A

Nitrosoureas

(Brain tumors)

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18
Q

Streptozocin

A

Nitrosoureas

[low Bone marrow toxicity]

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19
Q

Methotrexate

A

Antifolate

(Acute lymphocytic leukemia)

[Megaloblastic Anemia]

Has oral and IV preparation

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20
Q

Pemetrexed

A

Anti-folate

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21
Q

5-Flourouracil

A

Pyrimidine Analogs

(Breast, Colorectal CA)

[Megaloblastic anemia]

Linear dose-response curve

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22
Q

Capecitabine

A

Pyrimidine analogs

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23
Q

Azacitidine

A

Pyrimidine analogs

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24
Q

Cytarabine

A

Deoxycytidine Analogs

(AML, CML, ALL, CLL)

[Megaloblastic Anema, Neurotoxicity]

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25
Q

Gemcitabine

A

Pyrimidine Analogs

(Pancreatic, Bladder, Breast CA)

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26
Q

Fludarabine

A

Purine Antagonists

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27
Q

Cladribine

A

Purine Antagonists

(Hairy cell Leukemia)

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28
Q

6-Thiopurine

A

Purine Antagonists

(Childhood Acute Leukemia)

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29
Q

Mercaptopurine

A

Purine Antagonists

(Childhood Acute Leukemia)

has oral and IV preparation

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30
Q

Thioguanine

A

Purine Antagonists

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31
Q

Vincristine

A

Vinca Alkaloid

(Germ cell tumor, Kaposi’s Sarcoma)

[Neurotoxic, Areflexia]

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32
Q

Vinblastine

A

Vinca Alkaloids

(Rhabdomyosarcoma, Neuroblastoma, Wilm’s tumor, Acute Lymphocytic Leukemia)

[Neurotoxic, Areflexia]

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33
Q

Vinorelbine

A

Vinca Alkaloid

(non small cell lung CA)

[Neurotoxic, Areflexia]

34
Q

Paclitaxel

A

Taxanes

[Myalgia, Arthralgia]

35
Q

Docetaxel

A

Taxanes

36
Q

Etoposide

A

Epipodophyllotoxins

(small and non-small cell Lung CA)

[Diarrhea]

Oral or IV

37
Q

Tenoposide

A

Epipodophyllotoxins

(Acute Lymphocytic Leukemia)

[Diarrhea]

IV only

38
Q

Topotecan

A

Camptothecins

(Breast and Lung CA)

renal excretion

39
Q

Irinotecan

A

Camptothecins

(Colorectal CA)

Bile and feces excretion

40
Q

Doxorubicin

A

Anthracycline

[Cardiotoxic]

41
Q

Antracyclines

A

MOA:

  1. Topoisomerase II dependent DNA cleavage
  2. Generation of free radicals
  3. Intercalate with DNA double helix
    - Doxorubicin, Daunorobucin, Idarubicin, Epirubicin, Mitoxantrone

ADR: Vesicant

42
Q

Daunorobucin

A

Anthracyclines

[Cardiotoxic]

43
Q

Idarubicin

A

Anthracycline

44
Q

Epirubicin

A

Anthracycline

45
Q

Mitoxantrone

A

Anthracycline

[Blue discoloration of the fingernails and urine]

46
Q

Dactinomycin

A

Non-Anthracycline Anticancer Antibiotic

MOA: same as Anthracyclines

[Vesicant]

47
Q

Plicamycin

A

Non-Anthracycline Anticancer Antibiotic

MOA: complex with Mg & DNA; Blocks RNA synthesis

[Hepatotoxic]

48
Q

Mitomycin

A

Non-Anthracycline Anticancer Antibiotic

MOA: crosslinks between complementary strands of DNA –> impair replication

[HUS, Thrombocytopenia, Interstitial Pneumonitis]

49
Q

Bleomycin

A

Non-Anthracycline Anticancer Antibiotic

cell cycle specific (only)

MOA: DNA strand scission by interacting with O2 and Fe

[Pulmonary Fibrosis]

50
Q

Fluoxymesterone

A

Androgen

[Cholestatic jaundice]

51
Q

Flutamide

A

Androgen Antagonist

(Prostatic CA)

[Hot flushes, decreased libido, Impotence]

52
Q

Cyprotenone

A

Androgen Antagonist

53
Q

Firastemide

A

Androgen Antagonist

54
Q

Diethylstilbestrol

A

Estrogen

55
Q

Ethinylestradiol

A

Estrogen

56
Q

Tamoxifen

A

Estrogen Antagonist

(Breast CA)

[Hot flushes, osteoporosis]

57
Q

Hydroxycortisone

Prednisone

A

Corticosteroids

[Immunosuppression]

58
Q

Anastrozole

A

Aromatase Inhibitor

(Advanced ER/PR (+) Tamoxifen resistant Breast CA)

[Myelosuppression]

59
Q

Letrozole

A

Aromatase inhibitor

[Myelosuppression]

60
Q

Aminoglutethimide

A

Aromatse Inhibitor

[Myelosuppression]

61
Q

Leoprolide

A

Gonadotropin releasing Hormone

(Metastatic Prostatic CA)

62
Q

Goserelin

A

Gonadotropin Releasing Hormone

63
Q

Octreotide

A

Peptide Hormone

(GI cancer)

[Bradycardia]

64
Q

Growth Signal Reductors

(TAFT)

A
  • Tamoxifen
  • Aromatase Inhibitors
  • Fluvestrant
  • Toremefene
65
Q

Tyrosine Kinase Inhibitors

(DIN) “-nib”

A
  • Dasatanib
  • Imatinib
  • Nilotinib
66
Q

Her2 Inhibitors

A
  • Lapatinib
  • Trastuzumab
67
Q

EGRF Inhibitors

A
  • Panitumumab (Humanized)
  • Cetuximab (Chimeric)
68
Q

mTOR kinase Inhibitors

A
  • Temsirolimus
  • Everolimus
69
Q

Histone Deacetylases

A
  • Vorinostat
  • Romidespin
70
Q

Retinoid Receptors

(BAT) as in paniki

A
  • Bexarotene
  • Alitretinoin
  • Tretinoin
71
Q

Bortezonib

A

Proteasome Apoptosis Inducer

72
Q

Pralatrexate

A

RFC-1 Apoptosis Inducer

73
Q

VEGF inhibitors (Anti Angiogenesis)

A
  • Bevacizumab
  • Sunitinib
  • Sorafenib
74
Q

Treatment for the Adverse Drug reaction of Cisplatin

A

Amifostine

75
Q

Treatment for Metastatic Breast CA

A

Trastuzumab

76
Q

Drug Combination for Cervical CA

A

Cisplatin/Carboplatin + 5-Flourouracil

77
Q

Drug combination for Colon CA (3)

  • FOLFOX
  • FOLFIRI
  • CapeOx
A
  • FOLFIRI:
    • 5-FU + Leucovorin + Irinotecan/Topotecan
  • FOLFOX:
    • 5-FU + Leucovorin + Oxaliplatin
  • CapeOx
    • Capecitabine + Oxaliplatin
78
Q

Drug combination for ALL

A
  • Vincristine + Predisone (remission)
  • 6-Mercaptopurine + Methotrexate + Cyclophosphamide (Maintenance)
79
Q

Drug combination for AML

A
  • Cytarabine + Doxorubicin
80
Q

Drug Combination for CLL

A

Chlorambucil + Prednisone

81
Q

Drug used for Treatment of CML

A

Busulfan

82
Q
A

PHARMACOLOGY 3.0 (5 decks)

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