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Pharm > Anti-arrhythmics > Flashcards

Anti-arrhythmics Flashcards

1
Q

Class I blocks which channels?

A

Na

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2
Q

Class IA drugs

Abba performed dancing queen

A

Procainamide
Disopyramide
Quinidine

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3
Q

Class IA - MOA

Procainamide, Disopyramide, Quinidine

A

Block inward K rectifying channel (slow) at norm concentrations;
Blocks Na Channels (fast) at high concentrations

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4
Q

Class IA - Uses

Procainamide, Disopyramide, Quinidine

A

2nd line:

  • Afib/Flutter;
  • Paroxysmal SVT;
  • VT

(QT prolongation - proarrhythmic)

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5
Q

Class IB drugs

Backstreet Boys Majorly Lack Talent

A

Mexiletine
Lidocaine
Tocainide

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6
Q

Class IB - MOA

Mexiletine, Lidocaine, Tocainide

A

Blocks Na Channels in inactivated state mostly;

NO action on atrial tissue

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7
Q

Class IB - Uses

Mexiletine, Lidocaine, Tocainide

A

Digitalis toxicity

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8
Q

Class IC drugs

CRJ [even] More Freakin Painful

A

Moricizine
Flecainide
Propafenone

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9
Q

Class IC - MOA

Moricizine, Flecainide, Propafenone

A 
Most potent in class I;
Negative inotrope;
Blocks Na channels
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10
Q

Class IC - Uses

Moricizine, Flecainide, Propafenone

A

Afib/flutter;
Paroxysmal SVT;
VT

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11
Q

Class IC - Impt SE

Moricizine, Flecainide, Propafenone

A

Worsened HF;
Proarrhythmic in ischemic tissue;
Increased mortality

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12
Q

Class II Anti-arrhythmics

A

Beta Blockers

  • Propranolol
  • Carvedilol
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13
Q

Class II - MOA

Propranolol, Carvedilol

A

Blocks Beta receptors;
Dec SA and AV node activity;
Affects Phase 4 Depolarization

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14
Q

Class II - Uses

Propranolol, Carvedilol

A

Ventricular control:
Controls ventricular rate in Afib/flutter;
Prevent/terminate SVTs

(Dec mortality in CHF)

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15
Q

Class II - Impt SE

Propranolol, Carvedilol

A

Hypotension;
Bronchospasm;
Bradycardia

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16
Q

Class III Anti-arrhythmics

SAD ID

A

K Channel blockers

  • Sotalol
  • Amiodarone
  • Dofetilide
  • Ibutelide
  • Dronedarone
17
Q

Class III - MOA

  • Sotalol
  • Amiodarone
  • Dofetilide
  • Ibutelide
  • Dronedarone
A

Prolongs refractoriness by blocking K channels

18
Q

Class III (K) - Uses

  • Sotalol
  • Amiodarone
  • Dofetilide
  • Ibutelide
  • Dronedarone
A

Afib/flutter;
Paroxysmal SVT;
VT

Amiodarone - Shock refractory arrest

19
Q

Class III (K) - Impt SE

  • Sotalol
  • Amiodarone
  • Defetilide
  • Ibutelide
  • Dronedarone
A 
TDP;
QT prolongation;
Pulm fibrosis;
Peripheral neuropathy;
Hepatic dysfunction
20
Q

Class III (K) - Other SE

  • Sotalol
  • Amiodarone
  • Defetilide
  • Ibutelide
  • Dronedarone
A

Photosensitivity (blue-gray skin);

Numerous drug interactions

21
Q

Class IV anti-arrhythmic drugs

NAFIVD

A

Ca Channel Blockers

  • Nifedipine
  • Amlodipine
  • Felopidine
  • Isradipine
  • Verapamil
  • Diltiazem
22
Q

Class IV - MOA

  • Nifedipine
  • Amlodipine
  • Felopidine
  • Isradipine
  • Verapamil
  • Diltiazem
A

Blockade of L-type Ca Channels;
Slows SA and AV node activity;
Prolongs AV refractoriness

23
Q

Class IV (Ca) - Uses

  • Nefedipine
  • Amlodipine
  • Felodipine
  • Isradipine
  • Verapamil
  • Diltiazem
A

Prevent or terminate reentry SVTs

24
Q

Class IV (Ca) - Impt SE

  • Nefedipine
  • Amlodipine
  • Felodipine
  • Isradipine
  • Verapamil
  • Diltiazem
A

Hypotension;
Bradycardia;
Constipation;
Dizziness

25
Q

Class IV (Ca) - Other SE

  • Nefedipine
  • Amlodipine
  • Felodipine
  • Isradipine
  • Verapamil
  • Diltiazem
A

Increased serum Digoxin levels

26
Q

Class IV (Ca) - Contraindications

  • Nefedipine
  • Amlodipine
  • Felodipine
  • Isradipine
  • Verapamil
  • Diltiazem
A

WPW

27
Q

Adenosine

MOA

A

Adenosine receptors in atrium, SA and AV node;

Activates K current –> shortening AP, hyperpolarizing tissue, and slowing down automaticity/AV conduction

28
Q

Adenosine

Uses

A

AF;

Paroxysmal SVT

29
Q

Adenosine

Impt SE

A

Sedation
Dyspnea
Hypotension

30
Q

Digoxin

MOA

A

Na/K pump inhibitor;

Slows AV node activity and conduction

31
Q

Digoxin

Uses

A

Afib/flutter;

Chronic SVT

32
Q

Digoxin

Impt SE

A

Nausea;
Cognitive dysfunction;
Blurred/yellow vision

33
Q

Digoxin

Other SE

A

DAD arrhythmias

34
Q

Digoxin

Misc

A

Low Therapeutic Index

35
Q

Magnesium Sulfate

Uses

A

Prevents reccurent Torsades de Pointes and some digitalis-induced arrhythmias

36
Q

Magnesium sulfate

Misc

A

Alternative to Amiodarone for Shock-refractory cardiac arrest

Pharm (7 decks)

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