anti-arrhythmic drugs Flashcards

1
Q

Which channels do class 1a,b,c block

A

Na channels
Phase 0

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2
Q

Name a class 1A drug

A

Procainamide

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3
Q

Procainamide MOA

A
  1. reduces rate of Phase 0 rise
  2. increases effective refactory period ERP
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4
Q

Name a class 1B drug

A

Lidocaine

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5
Q

Lidocainem MOA

A
  1. reduces rate of phase 0 rise
  2. shortens phase 3 repolarisation
  3. reduce APD
  4. no change to ERP
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6
Q

Name a class 1C drug

A

Flecainide

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7
Q

Flecainide MOA

A
  1. reduces rate of phase 0 rise
  2. shortens phase 3 repolarisation
  3. no change to ADP and ERP
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8
Q

What are class 2 drugs

A

beta blockers
1. metoprolol
2. propranolol

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9
Q

beta blockers MOA

A
  1. reduce phase 4 depolarisation
  2. reduce HR and contractility
  3. no change in erp
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10
Q

beta blockers CVS clinical uses

A
  1. tachycardia
  2. atrial fibrillation
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11
Q

What channel does class 3 block

A

potassium channels

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12
Q

Name a class 3 drug

A

amiodarone

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13
Q

Amiodarone MOA

A
  1. prolongs phase 3 repolarisation
  2. increases ERP and APD
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14
Q

Amiodarone clinical uses

A
  1. normal sinus rhythm in patients with atrial fibrillation
  2. reentrant ventricular tachycardia
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15
Q

Amidarone adverse effects

A

bradycardia and heart block

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16
Q

What channels to class 4 block

A

calcium channel blockers
(non-DHP channel bloclers have higher selectivity for AV nodal calcium channels)

17
Q

Name 2 drugs in class 4

A

verapamil and diltiazem

18
Q

Verapamil and diltiazem MOA

A

increases ADP and ERP

19
Q

Verapamil clinical uses

A
  1. supraventricular tachycardia
  2. hypertension (not the best)
  3. angina
20
Q

Verapamil adverse effects

A

hypotension
contraindicated in patients with preecisting depressed cardiac fx

21
Q

Adenosine MOA

A
  • supress AV nodal conducrion
  • increase AV nodal refactory period
  • stimulates cardiac K+ channel
  • inhibits calcium current
  • half life less than 10s
22
Q

Adenosine clinical use

A

supraventricular tachycardia

23
Q

adenosine adverse effects

A
  1. flushing
  2. shortness of breath
  3. chest burning
  4. induction of AV block/ AF
    5.headache
  5. hypotension