anti-arrhythmic drugs Flashcards
1
Q
Which channels do class 1a,b,c block
A
Na channels
Phase 0
2
Q
Name a class 1A drug
A
Procainamide
3
Q
Procainamide MOA
A
- reduces rate of Phase 0 rise
- increases effective refactory period ERP
4
Q
Name a class 1B drug
A
Lidocaine
5
Q
Lidocainem MOA
A
- reduces rate of phase 0 rise
- shortens phase 3 repolarisation
- reduce APD
- no change to ERP
6
Q
Name a class 1C drug
A
Flecainide
7
Q
Flecainide MOA
A
- reduces rate of phase 0 rise
- shortens phase 3 repolarisation
- no change to ADP and ERP
8
Q
What are class 2 drugs
A
beta blockers
1. metoprolol
2. propranolol
9
Q
beta blockers MOA
A
- reduce phase 4 depolarisation
- reduce HR and contractility
- no change in erp
10
Q
beta blockers CVS clinical uses
A
- tachycardia
- atrial fibrillation
11
Q
What channel does class 3 block
A
potassium channels
12
Q
Name a class 3 drug
A
amiodarone
13
Q
Amiodarone MOA
A
- prolongs phase 3 repolarisation
- increases ERP and APD
14
Q
Amiodarone clinical uses
A
- normal sinus rhythm in patients with atrial fibrillation
- reentrant ventricular tachycardia
15
Q
Amidarone adverse effects
A
bradycardia and heart block