Anti-adrenergics

Question 1

Prazosin

Answer 1

Selective, reverisble a1 blocker

HTN, BPH

Question 2

Phenoxybenzamine

Answer 2

Irreversible alpha blocker
Semi selective, a1 but also some a2
Long duration of action (must resynth)
Pheocytoma, BPH

Question 3

Phentolamine

Answer 3

non selective reversible alpha1/2 block
A1 block: dec BP
A2 block: prevents feedback, worse tachycardia

Question 4

Pheochromcytoma tx

Answer 4

Phenoxybenzamine + phentolamine w/ propanolol

Question 5

BPH tx

Answer 5

Phenoxybenzamine, prazosin, terazosin

Question 6

Side effects of alpha blockers

Answer 6

Postural hypotension
Reflex tachycardia
Nasal stuffiness
Inhibition of ejaculation

Question 7

What is epinephrine reversal?

Answer 7

When the pressor effect of epinephrine as been converted to a pure depressor effect d/t presence of alpha blocker (will only have its actions at B2 receptors –> dilation)

Question 8

Nonselective beta blocker

Answer 8

Propanolol
B1 block: dec HR/contractility, dec renin
B2: may inc TPR but dec renin wins therefore drop in BP,also causes bronchoconstriction

Question 9

Timolol

Answer 9

Nonselective beta blocker used in glaucoma to reduce aqueous humor production

Question 10

Atenolol

Answer 10

Selective beta blocker

Less danger of respiratory effects

Question 11

Side effects of beta blockers

Answer 11

B1 block: dec CO, heart block, bradycardia
B2: bronchoconstriction
CNS: depression, lethargy

Question 12

Why are a2 agonists considered anti-adrenergic?

Answer 12

Because they turn off NE release via feedback mechanism at a2

Question 13

Clonidine

Answer 13

Alpha 2 blocker, directly
Opioid w/d
ADHD
Dry mouth, sedation 
Hypertensive crisis upon w/d

Question 14

methyldopa

Answer 14

A2 blocker, must be metabolized first
Safe in pregnant HTN
High incidence of autoimmune response
Dry mouth, sedation