Antenatal Flashcards
What is gestational diabetes
Reduced insulin sensitivity ( carbohydrate intolerance) during pregnancy which may or may not resolve after birth
Give 5 RFs for gestational diabetes
- Previous gestational diabetes
- Previous macrosomic baby (≥ 4.5kg)
- BMI > 30
- black Caribbean, Middle Eastern and South Asian origin
- Polyhydramnios
- First gen FHx of diabetes
What is the screening test of choice for gestational diabetes
oral glucose tolerance test
What time of day should an Oral Glucose Tolerance Test (OGTT) be performed?
In the morning after a fast (patient can drink plain water).
When should individuals with risk factors for gestational diabetes be screened?
With an oral glucose tolerance test (OGTT) at 24–28 weeks gestation
When do women with a history of previous gestational diabetes have an OGTT?
as soon as possible after the booking clinic and subsequently at 24-28 weeks
Describe the oral glucose tolerance test
- patient drinks a 75g glucose drink at the start
- blood sugar level is measured before the sugar drink (fasting) and then at 2 hours
What are the diagnostic thresholds on an OGTT for gestational diabetes
- fasting glucose >= 5.6mmol/L
- 2 hour glucose >= 7.8mmol/L
How is gestational diabetes managed
- joint diabetes and antenatal clinics
- education - self monitoring of glucose, exercise, diet
- Fasting glucose <7 mmol/l: trial of diet and exercise for 1-2 weeks
- fasting glucose >7 mmol/l: start short acting insulin ± metformin
- Fasting glucose >6 mmol/l plus macrosomia (or other Cx): start insulin ± metformin
How is gestational diabetes managed in a woman with a fasting glucose <7mmol/L
- trial of exercise for 1-2w
- if glucose targets not met within 1-2w then start metformin
- if glucose targets still not met, add short acting insulin
What medication is suggested for women who decline insulin or cannot tolerate metformin in the management of gestational diabetes?
Glibenclamide - sulfonylurea
How is gestational diabetes followed up postnatally
test fasting glucose at 6 weeks
How are pregnant women with pre-existing diabetes managed
- folic acid 5 mg/day from pre-conception to 12 weeks gestation
- aspirin 75-150mg daily from 12 weeks gestation until the birth
- retinopathy screening
- stop oral hypoglycaemic agents, apart from metformin, and commence insulin
- planned delivery between 37 and 38+6 w
- tight glycaemic control
What are the self-monitoring blood sugar targets for pregnant women with gestational and pre-existing diabetes?
- Fasting: 5.3 mmol/l
- 1 hour post-meal: 7.8 mmol/l
- 2 hours post-meal: 6.4 mmol/l
- Avoid levels of 4 mmol/l or below.
What are the risks to babies of mothers with diabetes?
- Neonatal hypoglycaemia
- Polycythaemia (raised haemoglobin)
- Jaundice (raised bilirubin)
- Congenital heart disease
- macrosomia -> birth trauma
When are women routinely screened for anaemia during pregnancy?
At the booking clinic and again at 28 weeks gestation
What causes anaemia in pregnancy
During pregnancy, the plasma volume increases. This results in a reduction in the haemoglobin concentration. The blood is diluted due to the higher plasma volume.
What are the normal ranges for haemoglobin during pregnancy
- First trimester: > 110 g/l
- Second/third trimester: > 105 g/l
- Post partum: > 100 g/l
What screening for haemoglobinopathy is offered to women at the booking clinic?
- Thalassaemia screening for all women.
- Sickle cell disease screening for women at higher risk.
Give 3 maternal complications of sickle cell in a pregnant woman
- crisis
- thrombosis
- pre-eclampsia
Give 2 fetal complications of sickle cell in their mother
- intrauterine growth retardation
- increased perinatal mortality
How is sickle cell managed in pregnancy
- folic acid 5mg
- aspirin
- penicillin V
- LMWH
In a pregnant woman with hypertension, which 3 antihypertensive medications should be stopped due to teratogenicity
- ACE inhibitors (e.g. ramipril)
- Angiotensin receptor blockers (e.g. losartan)
- Thiazide and thiazide-like diuretics (e.g. indapamide)
Give 3 antihypertensive drugs that are safe to use in pregnant women with existing hypertension
- Labetalol (a beta-blocker )
- Calcium channel blockers (e.g. nifedipine)
- Alpha-blockers (e.g. doxazosin)
Give some RFs of VTE in pregnancy and state their risk level
- Prev VTE - high
- thrombophilia - high/med
- prolonged hospitalisation - med
- co-morbidities - med
- surgery - med
- age >35
- BMI >30
- Parity >3
- smoking
- multiple pregnancy
- gross varicose veins
- immobility
- current pre-eclampsia
- FHx
When should VTE prophylaxis be initiated in pregnant women
- 3 RFs: From 28 weeks till 6w postnatal
- ≥ 4 RFs: immediate treatment continued until 6 weeks postnatal
- if there’s a single high/ medium risk factor - as above
What is the pharmacological prophylaxis for VTE in pregnancy
Low molecular weight heparin (LMWH) unless contraindicated.
Eg. enoxaparin, dalteparin and tinzaparin
What is the protocol for VTE prophylaxis during and after labour?
Prophylaxis is temporarily stopped when the woman goes into labor and can be started immediately after delivery (except with PPH, spinal anaesthesia, and epidurals.
What is the recommendation for anticoagulation treatment if a DVT is diagnosed shortly before delivery?
Continue anticoagulation treatment for at least 3 months.
What are the options for mechanical VTE prophylaxis in pregnant women with contraindications to LMWH?
- Intermittent pneumatic compression (equipment that inflates and deflates to massage the legs).
- Anti-embolic compression stockings.
What is intrahepatic cholestasis of pregnancy
characterised by the reduced outflow of bile acids from the liver in a pregnant woman
(aka obstetric cholestasis)
When does obstetric cholestasis typically present?
Later in pregnancy, particularly in the third trimester.
Give 3 features of obstetric cholestasis
- pruritis - typically worse on palms, soles and abdomen
- jaundice (uncommon)
- excoriations without a rash
What fetal complication is associated with obstetric cholestasis?
increased risk of stillbirth.
How is obstetric cholestasis investigated
- LFTs - abnormally raised
- raised bile acids
How is obstetric cholestasis managed
- topical emollients - soothe skin
- antihistamine (e.g. chlorphenamine) - help sleep
- monitoring LFTs and bile acids
- ursodeoxycholic acid - reduce severity of pruritis
- vitamin k supplements
- induction of labour at 37-38w if [bile acids] >100micromol/L
Define gravidity
the total number of pregnancies a woman has had
Define parity
the number of times the woman has given birth after 24 weeks gestation, regardless of whether the fetus was alive or stillborn
Define gestational age
refers to the duration of the pregnancy starting from the first day of the last menstrual period
What are the 3 trimesters of pregnancy
- first - from the start of pregnancy until 12 weeks gestation
- second trimester - from 13 weeks until 26 weeks gestation
- third trimester - from 27 weeks gestation until birth
At what gestation do fetal movements typically start
20 weeks
In pregnancy, what is the dating scan and when should it be done
- ultrasound to determine accurate gestational age using crown-rump length, also detects multiple pregnancies
- between 10 and 13+6 weeks
What is the basic antenatal schedule recommended for women with uncomplicated pregnancies
- 16w - Information on the anomaly and the blood results. If Hb < 11 g/dl consider iron. Routine care: BP and urine dipstick
- 18 - 20+6w - anomaly scan
- 25, 28, 31, 34, 36, 38, 40 and 41w - routine care
- scans at 25, 31 and 40 weeks are only done for nulliparous women
What are the key assessments and discussions during routine antenatal appointments?
- Discuss plans for the remainder of the pregnancy and delivery
- Symphysis–fundal height measurement from 24 weeks onwards
- Fetal presentation assessment from 36 weeks onwards
- Blood pressure
- Urine dip
What screening programmes are offered to all pregnant women
- Infectious diseases in Pregnancy Screening Programme (hep B, syphilis, HIV)
- Sickle Cell and Thalassaemia Screening
- Fetal Anomaly Screening Programme (Down’s syndrome, Edwards’ syndrome and Patau’s syndrome)
Name a haemoglobinopathy screened for in high risk pregnant women
sickle cell disease
What is the advice on vitamin supplementation in pregnant women
- folic acid 400mcg from before conception till 12w
- avoid vitamin A as can be teratogenic in high doses
- 10mcg Vit D daily
What conditions are risk assessed in women during antenatal appointments, and what plans are made for high-risk conditions?
- Rhesus negative (book anti-D prophylaxis)
- Gestational diabetes (book oral glucose tolerance test)
- Fetal growth restriction (book additional growth scans)
- VTE (provide prophylactic LMWH if high risk)
- Pre-eclampsia (provide aspirin if high risk)
What is the standard screening test for down’s syndrome antenatally
- combined test