Antacids Flashcards
Antacids (usually containing ____________ or ___________ compounds) can often relieve symptoms in ulcer dyspepsia and in non-erosive gastro-oesophageal reflux
aluminium
magnesium
Antacids (usually containing aluminium or magnesium compounds) can often relieve symptoms in ________________ and in ___________________
ulcer dyspepsia
non-erosive gastro-oesophageal reflux
When should antacids be taken?
Should be given when symptoms occur or are expected ie usually between meals and at bedtime (although additional doses may be required)
Conventional doses of liquid magnesium–aluminium antacids promote ________________, but less well than antisecretory drugs
ulcer healing
Conventional doses of liquid magnesium–aluminium antacids promote ulcer healing, but less well than _________________ drugs
antisecretory
______________ antacid preparations are more effective than _____________ preparations
Liquid
tablet
Aluminium- and magnesium-containing antacids (e.g. aluminium hydroxide, magnesium carbonate, co-magaldrox and magnesium trisilicate), being relatively insoluble in water, are __________-acting if retained in the stomach.
Long
Magnesium-containing antacids tend to be ____________ whereas aluminium-containing antacids may be ___________
laxative
constipating
Antacids containing both ______________ and ____________ may reduce colonic side-effects
magnesium
aluminium
Is the accumulation of aluminum content of some antacids associated with toxicity?
Aluminum accumulation does not appear to be a risk if renal function is normal
__________________ should no longer be prescribed alone for the relief of dyspepsia but it is present as an ingredient in many indigestion remedies. However, it retains a place in the management of urinary-tract disorders and acidosis.
Sodium bicarbonate
_____________-containing antacids (unless chelates) are not recommended because when absorbed can be neurotoxic, causing encephalopathy; they tend to be constipating.
Bismuth
Bismuth-containing antacids (unless chelates) are not recommended because absorbed bismuth can be ________________, causing ______________; they tend to be constipating.
neurotoxic
encephalopathy
___________-containing antacids can induce rebound acid secretion: with modest doses the clinical significance is doubtful, but prolonged high doses also cause _____________ and _____________, and can precipitate the _____________ syndrome.
Calcium
hypercalcaemia
alkalosis
milk-alkali
Calcium-containing antacids can induce _______________: with modest doses the clinical significance is doubtful, but prolonged high doses also cause hypercalcaemia and alkalosis, and can precipitate the milk-alkali syndrome.
rebound acid secretion
