ANS Pharm Flashcards
Alpha-1 receptors
Increase vascular smooth muscle contraction
Alpha-2 receptors
Decrease sympathetic outflow
Beta-1 receptors
Increase HR and contractility
Beta-2 receptors
Increase vasodilation, HR, and contractility
Alpha-1 receptor G-protein activity
Works via phospholipase C to increase calcium and smooth muscle contraction
Beta-1 and beta-2 G-protein activity?
Increase cAMP which releases more calcium in the heart and inhibits MLCK
Cardiac MOA of atropine?
Treats bradycardia
Epinephrine selectivity?
Beta > alpha
NE selectivity?
alpha 1 > alpha 2 > beta
Distribution of alpha and beta receptors?
More alpha than beta
Isoproterenol selectivity
beta 1 = beta 2
Use of NE/epi?
Hypotension
Use of isoproterenol?
Electrophysiologic eval of tachyarrhythmias
Dobutamine selectivity?
beta 1 > beta 2, alpha
Use of dobutamine?
Heart failure, cardiac stress testing
Selectivity of phenylephrine?
alpha 1 > alpha 2
Use of phenylephrine?
Hypotension
What does cocaine do?
General indirect agonist of sympathetic receptors. Do not give beta blockers in presence of cocaine for fear of causing unopposed alpha 1 activation and extreme hypertension.
What are two alpha-2 agonists?
Clonidine and alpha-methyldopa
Applications of clonidine?
HTN urgency
Application of alpha-methyldopa
HTN in pregnancy
Alpha-methyldopa AE?
Direct coombs + hemolytic anemia and SLE-like syndrome.
What are the two nonselective beta-blockers (alpha and beta antagonists)
Carvedilol and labetalol
What are the selective beta-blockers (beta 1 selectivity)?
A through M
