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EOB - Blood Cardio > ANS Pharm > Flashcards

ANS Pharm Flashcards

1
Q

Alpha-1 receptors

A

Increase vascular smooth muscle contraction

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2
Q

Alpha-2 receptors

A

Decrease sympathetic outflow

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3
Q

Beta-1 receptors

A

Increase HR and contractility

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4
Q

Beta-2 receptors

A

Increase vasodilation, HR, and contractility

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5
Q

Alpha-1 receptor G-protein activity

A

Works via phospholipase C to increase calcium and smooth muscle contraction

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6
Q

Beta-1 and beta-2 G-protein activity?

A

Increase cAMP which releases more calcium in the heart and inhibits MLCK

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7
Q

Cardiac MOA of atropine?

A

Treats bradycardia

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8
Q

Epinephrine selectivity?

A

Beta > alpha

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9
Q

NE selectivity?

A

alpha 1 > alpha 2 > beta

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10
Q

Distribution of alpha and beta receptors?

A

More alpha than beta

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11
Q

Isoproterenol selectivity

A

beta 1 = beta 2

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12
Q

Use of NE/epi?

A

Hypotension

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13
Q

Use of isoproterenol?

A

Electrophysiologic eval of tachyarrhythmias

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14
Q

Dobutamine selectivity?

A

beta 1 > beta 2, alpha

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15
Q

Use of dobutamine?

A

Heart failure, cardiac stress testing

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16
Q

Selectivity of phenylephrine?

A

alpha 1 > alpha 2

17
Q

Use of phenylephrine?

A

Hypotension

18
Q

What does cocaine do?

A

General indirect agonist of sympathetic receptors. Do not give beta blockers in presence of cocaine for fear of causing unopposed alpha 1 activation and extreme hypertension.

19
Q

What are two alpha-2 agonists?

A

Clonidine and alpha-methyldopa

20
Q

Applications of clonidine?

A

HTN urgency

21
Q

Application of alpha-methyldopa

A

HTN in pregnancy

22
Q

Alpha-methyldopa AE?

A

Direct coombs + hemolytic anemia and SLE-like syndrome.

23
Q

What are the two nonselective beta-blockers (alpha and beta antagonists)

A

Carvedilol and labetalol

24
Q

What are the selective beta-blockers (beta 1 selectivity)?

A

A through M

25
Q

What are the nonselective beta-blockers (beta 1 = beta 2)?

A

N through Z

26
Q

Angina effects of beta-blockers?

A

Decreased HR and contractility

27
Q

HTN effects of beta blockers?

A

Decreased CO, decreased renin secretion

28
Q

CHF effects of beta blockers?

A

Slows progression of chronic failure.

29
Q

Main toxicity of metoprolol?

A

Dyslipidemia

EOB - Blood Cardio (5 decks)

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