ANS Parasympatholytics or Antimuscarinics

Question 1

Atropine

Answer 1

muscarinic antagonist, competitive. natural, CNS long duration. prevents IP3 release. salivary, bronchial, sweat glands most sensitive. parietal cells least sensitive. rapid 2hr and slow 13 hr phases, rapid decline in all but eye. varied dose response: slight bradycardia to tachycardia to severe cardiac + CNS systems. inhibit excessive salivation + sweating, treat organophosphate poisoning

Question 2

Scopolamine

Answer 2

muscarinic antagonist, competitive. natural, CNS long duration. central effects at low therapeutic doses. absorbed across skin. treat motion sickness, inhibit excessive salivation

Question 3

Homatropine + Tropicamide

Answer 3

muscarinic antagonist, competitive. semisynthetic, shorter duration of action

Question 4

Ipratropium

Answer 4

muscarinic antagonist, competitive. semisynthetic, does not cross BBB. treat asthma + COPD

Question 5

Pirenzepine

Answer 5

muscarinic antagonist, competitive. semisynthetic, M1. treat peptic ulcer

Question 6

Tolterodine

Answer 6

muscarinic antagonist, competitive. semisynthetic, M3. treat bladder spasm, incontinence