ans basics Flashcards
sns only innervates
bv and sweat glands
M1
cholinergic G alpha q - excites CNS PLC/ip3 and dag/pkc= increase Ca and decrease K conductance Clinical- Increase sensor and modulation
M2
g alpha I
inhibit cardiac
inhibit Adenyl Cyclase= decrease cAMP, Increase K conductance
Clincial- decrease cAMP= decrease HR and contractility
M3
g alpha Q
excitation of smooth muscle and GLANDS
PLC/IP3 and dag/increase Ca
Clincal= SM contraction
alpha 1
Galpha q
excite BV
PLC/IP3 and dag/PKC and icnrease Ca
clin- SM constriction
alpha 2
G alpha I (acts pre and post syn for Neg FB)
inhibit BV
inhibit adenyl cyclase and decrease cAMP/increase Kconductance
Clin- decrease cAMP= increase SM/ increase in K= hyperpolerization
B123
g alpha s
excites/inhibits
activates adenyl cyclase= increase cAMP,
clin= increase cAMP= relaxes SM and stimulates cardiac contraction and increases rate
Nn
ligand
excites CNS
increase NA/K conductance
depolarization
Nm
ligand
excites at NMJ
increases NA/K conductance
depolarization
all presynaptic neurons are….
Nicotinic aCh receptors
where are alpha 1
blood vessels heart iris prostate/uterus pilomotor smooth muscle
where are alpha 2
platelets cns go vascular smooth muscle adrenergic and cholenergic receptors
where are beta 1
heart and kidneys
where are beta 2
lungs mast cells smooth muscle liver pancreas adrenergic nerve terminal
where are dopamine 1
smooth muscle- post synaptic
