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SMUPASPG19-PHARM 1 > ANS > Flashcards

ANS Flashcards

1
Q

ANS

A

Parasympathetic- Periphery NS, Autonomic, CIII, VII, IX, X, S2-S4
Sympathetic- Periphery NS, Autonomic, T1-T12, L1-L5, may Sacral
Under unconscious controll
Afferent- Away/Activity to CNS
Efferent- Exit/ Effects to Periphery (smooth muscle, cardia, exocrine

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2
Q

Somatic receptors and TMs

A

NT- AcH
Receptor- Nicotinic
Skeletal muscles
NO Ganglions

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3
Q

PSNS receptors and TMs

A

Cranial and Sacral
PSNS-Presynaptic/Preganglion: LONGER
NT- ACH,
Receptor- Nicotinic.

Postsynaps/Postganglion: Shorter closer to organs (cardia, smooth muscle, gland,
NT-ACH, Receptor- Muscunaric

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4
Q

SNS receptors and TMs

A

Presynaptic/Preganglion: Shorter very close to ganglion
NT- ACH,
Receptor: Nicotinic ganglion

Postsynaps/Postganglion: Longer
Sweat Glands-NT-ACH, Receptor- Muscarinic

NT-EPI, NE, ACH, Receptor-Nicontinic on Adrenal medulla

Cardiac, smooth muscle, glands
NT-NE
Receptor- Alpha and Beta

Renal, vessels-
NT-NE, Dopamine
Receptor- Alpha1 or Dopamine1

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5
Q

PSNS

A

Rest and digest
NT- ACH
AKA Cholnergic
Receptors- M1-M5

ACH-synthezies in vessecal via cholin acetylyintranferase
Acetycholnieresrase- breaks down ACH at synaptic cleft

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6
Q

PSNS on Eye

A

Agonist (or ACH RX) effect on Muscarinic receptor
Iris spincter (CN III) constricts miosis pupil
Iris radial- no effect
Cillary- contracts, lens relaxed/shorten for near vision

Think PS relax, no danger to see clear or far.

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7
Q

PSNS Heart

A

Agonist (or ACH RX) effect on Muscarinic receptor
SA node- decelarates
Contracil-decrease

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8
Q

PSNS Blood Vessels

A

Agonist (or ACH RX) effect on Muscarinic receptor
releases endothelium derived relaxin factor
Vasodialtion

Relaxed/Rest- Blood flow everywhere

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9
Q

PSNS Bronchial

A

Agonist (or ACH RX) effect on Muscarinic receptor
smooth muscles- contracts
Glands- sercrete
Rest- all working

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10
Q

PSNS GI

A 
Agonist (or ACH RX) effect on Muscarinic receptor
inc. motility and tone
relaxes sphincter
increase secretion
ADE- diaharreah
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11
Q

PSNS Bladder

A

Agonist (or ACH RX) effect on Muscarinic receptor
Detrusor- contracts (squeeze pee out)
Trigone spincter- relaxers (opens)

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12
Q

PSNS Salivary/Lacrimal glands/sweat Glands

A

Agonist (or ACH RX) effect on Muscarinic receptor

Secretions

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13
Q

PSNS Kidney

A

Agonist (or ACH RX) effect on Muscarinic receptor

NONe

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14
Q

PSNS Uterus

A

Agonist (or ACH RX) effect on Muscarinic receptor

Contracts

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15
Q

PSNS GU

A

Agonist (or ACH RX) effect on Muscarinic receptor

Erection

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16
Q

PSNS Liver, Fat

A

Agonist (or ACH RX) effect on Muscarinic receptor

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17
Q

PSNS Pancreas

A

Agonist (or ACH RX) effect on Muscarinic receptor

18
Q

SNS on Eye

A

Agonist (or RX) effect on Alpha Beta receptor
A1 radial contracts smooth muscle, mydriais (dialtion
B1 B2- relaxes cilary muscle- far vision

19
Q

SNS Heart

A

Agonist (or RX) effect on Alpha Beta receptor

B1 B2- increase rate and contraction

20
Q

SNS Blood Vessels

A

Agonist (or RX) effect on Alpha Beta receptor
Coronary
A1 A2- constricts B2- dilates

Renal
A1 A2- constricts, B1 B2- dilates

Skeletal
A1A2- constricts, B2- dilates

Veins
A1 A2- constricts B2- dilates

21
Q

SNS Bronchial

A

Agonist (or RX) effect on Alpha Beta receptor
A1 glands dec secretions, B2-inc
B2-relax

22
Q

SNS GI

A

Agonist (or RX) effect on Alpha Beta receptor
A1 A2
B1 B2

23
Q

SNS Bladder

A 
Agonist (or RX) effect on Alpha Beta receptor
Detrusor
B23-relaxed
Trigone Spinc
A1- contraction
24
Q

SNS sweat glands

A

Agonist (or RX) effect on Alpha Beta receptor

A1 - secretions

25
Q

SNS Kidney

A

Agonist (or RX) effect on Alpha Beta receptor
Renin secretion
A1- decreased
B1- increase

Ureters-A1
increase tone smooth mus

26
Q

SNS Uterus

A

Agonist (or RX) effect on Alpha Beta receptor
A1- contractions
B2- relaxation

27
Q

SNS GU

Skeletal

A

Agonist (or RX) effect on Alpha Beta receptor
A1 -Ejaculations

Skeletal
B2-contract, glyogenolyisis

28
Q

SNS Liver, Fat

A

Agonist (or RX) effect on Alpha Beta receptor
A1, B2- glycogenolyis, gluconeogenesis (Inc. DM)

Fat
A1B13- lypolysis

29
Q

SNS Pancreas

A

Agonist (or RX) effect on Alpha Beta receptor
A1 A2- dec secretions
B2-inc. secretions

30
Q

PSNS RX PSmimetics (mimic PSNS)

Cholinesterase inhibitors

A 
Stem "chol"
INDIRECT ACTs ON ACETYCHOLINESTERASE INHIBITORS
thus limits this enzyme to break down ACH. T
ACH is INCREASED
SLUD...ADE
SALVIATION
LACRIMATIN
URINATION
DIARRHEA
31
Q

Asthma

A

anticholerngic to decrease secretions, but stimulate SNS (fight or flight) not relaxed, no wonder attacks

32
Q

Parasympatholytics

A 
lysis of PNS, dec ACH, get SNS resutls
ANTICHOLINERGIC EFFECT
USED preop-dec salivation, secretons, improve bradycardia
Direct acting ANTAGONISTS ON M1-M5 RECEPTORS
dry mouth
mydriasis- constricted pupil
skin hot
CNS confusion
constipation
Airway dialtion, secretion reduced
Urinary retention
Tachycardia
ADE- DRY AS A BONE, BLINDA AS A BAT, RED AS A BEET, MAD AS A HATTER

CONTRA- GERD (SLOW EMPTY, ACID SITS)
GLAUCOME, URINARY RENTION, DEMENTIA

33
Q

Sympathetic NS
Ergotrophic
Andrenergic System

A 
NE-Noradrenaline
Epi- adrenaline
Adrenal gland
(ACH for sweat glands)
VAMPS and SNAP
34
Q

Alpha 1 receptors

A

post synaptic effector- smooth muscle
Ex. alpha agonist= affe t autoreceptor= stop CA influx= DEC NE
1a, b, d

35
Q

Alpha 2 receptors

A

Adrenergic System (SNS)
pre and post synpatic receptors on platelets, smooth muscle
2a, b, c

36
Q

Beta 1 receptor

A

Adrenergic System (SNS)
65% receptors on Heart,
post synaps. cilary body

37
Q

Beta 2

A

Adrenergic System (SNS)
30% beta 2
post synap- smooth muse and heart, lungs
Asthma- Beta 2 agonist anticholinergic= dec secretions d/t asthma/Cholernergic agonist

38
Q

Beta 3

A

Adrenergic System (SNS)
post synap
Adipose issue heart and bladder
recent

39
Q

Dopamine

A

Adrenergic System (SNS)
D1-5
Brain, renal

40
Q

Adrenergic NTs

A

NE and Dopamine, (ACH) sweat glands
Termination- reuptake, cells, diffusion,
Dopamine (Monamine oxidase?) D-hydroxydase to NE
NE (via enzymePhenlyethanolamine) to Epinephrine
REuptake stops

41
Q

NMJ ACh synthesis

A

AP arrives at Pre synatpic
Open Ca gate
CA flow in mobilies Ach storage in vesicle
Ach releases bind to post ganglion receptor

42
Q

NMJ synaps terminoation

A

Acetycholineresas AchE degrade ACH

AchE inhibitor= INCEASE ACH

SMUPASPG19-PHARM 1 (17 decks)

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