Anorectal Disorders Flashcards
Red flags of colorectal cancers?
- Melana, hematochezia
- Altered bowel movements
- Unexplained weight loss
- Unexplained iron deficiency anemia
What are anal fissures?
Linear (longitudinal) or oval shaped ulcer or tear in the anal mucosa
What condition is among one of the main causes of anal pain?
Anal fissures
Usually, how long are anal fissures?
Usually <5mm in length
What are the two types of anal fissures?
- Acute (<8 weeks)
- Chronic (>8 weeks)
Most anal fissures occur where?
In the posterior midline of the anal canal (99% in men, 90% in women)
10% of anal fissures are located where?
In the anterior midline
*more common in females than males
Which anal fissures are atypical and should raise suspicion for secondary conditions?
Fissures that occur off midline (laterally)
Which secondary conditions should be considered if atypical lateral/off-midline fissures occur?
Crohn’s, HIV/AIDS, TB, Syphilis, malignancy (ex. anal carcinoma)
A majority of anal fissures are caused by what?
Local trauma: Straining, penetration/anal sex, constipation, diarrhea, vaginal delivery
Other causes of anal fissures are due to what?
Underlying disease: Crohn’s, STDs, HIV/AIDS, malignancy
Clinical manifestations of anal fissures?
-severe/sharp “passive knives/shards of glass” tearing pain w/ defecation followed by throbbing discomfort
-Can lead to constipation (fear of recurrent pain w/ defecation)
-Mild hematochezia (blood on outside of stool or on TP following BMs)
Physical exam findings of anal fissures?
-confirm by visual inspection of anal verge
-acute fissures look like cracks in epithelium
-anal tenderness
-digital/anoscopic exam may not be possible d/t pain (often deferred)
Chronic anal fissures can result in what?
Fibrotic changes, develop skin tag at fissure’s distal end (sentinel pile) & hypertrophied anal papilla at fissure’s proximal end
Anoscopy clock locations?
12 o’clock: Anterior
3 o’clock: Left
6 o’clock: Posterior
9 o’clock: Right
Dx of anal fissures based on what?
Hx and physical exam
When are no lab tests necessary for anal fissures?
If anal fissure is located in the posterior and anterior midline
If atypical lateral/off-midline fissures occur with suspicion of underlying conditions, which tests should be ordered?
ESR, Stool/viral cultures, HIV testing, Bx of lesion/fissure as warranted
Conservative treatment of anal fissures promotes what?
Effortless and painless bowel movements
Conservative tx for anal fissures?
High fiber diet/fiber supplements, stool softeners/laxatives, increased fluid intake, sitz baths for relief, topical anesthetics for sx relief, topical vasodilators
Topical anesthetics for conservative tx of anal fissures?
5% lidocaine, 2.5% lidocaine + 2.5% prilocaine
(sx relief)
Topical vasodilators for conservative tx of anal fissures?
0.4% nitroglycerin ointment, 2% diltiazem ointment, or 0.5% nifedipine ointment 2-3x/day x 4 weeks
*to the internal sphincter for healing
If symptoms of anal fissures continue after conservative treatment, what should be done?
Re-evaluate and continue w/ 4 more weeks of conservative tx
What should be performed if anal fissure sx continue after 8 weeks of conservative tx?
Endoscopy to exclude Crohn’s
If IBD is excluded: refer to colorectal surgeon
When is lateral internal sphincterectomy indicated when conservative tx is unsuccessful for anal fissures?
If patient has low risk of fecal incontinence
What is recommended for patients with high fecal incontinence risk when conservative tx for anal fissures fails?
Outpatient procedure w/ injection of botox (20 units) into internal anal sphincter to relieve spasm
or
Anal advancement flap
Anorectal abscess and fistulae represent what?
Different stages of the same anorectal infectious process
What is an anorectal abscess?
Acute manifestation of purulent infection most commonly developing from infected anal crypt gland –> 90% of cases (Anal crypts of Morgani)
How does an anal crypt gland become infected?
Gland becomes obstructed w thickened debris, permitting bacterial growth & abscess formation
What is a perianal fistula?
A tract (ductal connection) between the anorectal abscess and the anal canal or perianal skin
*chronic manifestation
Other causes of formation of anorectal abscesses/fistulae?
Crohn’s (IBD), infected anal fissures, secondary to trauma (obstetric, FB), Carcinoma, Radiation therapy, Actinomycoses bacterial infection (rare), Rectal TB, STIs (chlamydia, lymphogranuloma venerum)
Anorectal abscesses are a result of what?
Infection (aerobic and anaerobic bacteria)
Obstruction of anal glands by thick debris triggers what?
Stasis and bacterial overgrowth (E. coli, Proteus mirabilis, S. aureus) –> Abscess formation–>abscesses may extend into perirectal spaces –> possible fistula formation
When do anal fistulas form?
When abscesses ruptures/drains and forms and epithelial tract between anorectal abscess and perianal skin or rectum
Extension of anal abscess/fistula infection can involve what areas?
Intersphincteric, ischiorectal, or even supralevator space
The _______ and _______ of abscesses can vary
Severity and depth
Major types of anorectal abscesses are based according to what?
Anatomical location
Major types of anorectal abscesses?
- Perianal (MC)
- Ischiorectal (ischioanal)
- Intersphincteric (in between internal/external sphincters)
- Supralevator
What are the 4 types of fistula tracts (Parks’s Classification)?
I. Intersphinctereric fistula (MC)
II. Transsphincteric fistula
III. Suprasphincteric fistula
IV. Extrasphincteric fistula
Clinical manifestations of perianal abscesses?
Throbbing, continuous pain around the anus, erythematous palpable mass near anus, rectal pain worse w/ sitting/coughing/defecation, +/- fever
Clinical manifestations of perirectal (deeper) abscesses?
Buttock or coccyx pain, fever/chills more likely, rectal pain worse w/ sitting/coughing/defecation
Physical external exam in perianal regions for anorectal abscesses may have what characteristics?
Localized tenderness, erythema/warmth, swelling, fluctuant mass, purulent discharge if abscess is draining
Physical exam of deeper anorectal abscesses may cause what?
DRE showing rectal fullness/palpable mass, Boggy area of tenderness/fluctuance, EUA if clinical exam cannot be performed in office
Clinical manifestations of anal fistulae?
Perianal/anal canal discharge (bloody, purulent, malodorous/smelly), painful defecation, anal itching/pruritus
Physical exam of anal fistulae may show what?
Perianal skin may be excoriated/inflamed, external opening may be visualized or palpated as indurated just below skin, external opening may be inflamed/tender/draining fluid, palpable cord leading from external opening to anal canal
What is a EUA?
Exam performed under anesthesia
What does EUA avoid?
Probing in the office
Process of EUA?
Injection of H2O2 or povidone iodine allowing for visualization of bubbles at internal opening of anal fistulas
EUA must be done for anal fistulas before what?
Any surgical intervention
Digital rectal exam for anal fistulas hold what purpose?
Check sphincter tone before surgical intervention (for both abscess & fistulae), internal opening may be palpated in some cases
Anoscopy for anal fisulas allows for viewing of what?
Internal opening in the anus (but EUA often necessary)
Proctosigmoidoscopy inspection can be used to inspect for what with anal fistulas?
Underlying disease processes, can view opening in the rectum
If the anorectal abscess is deep, and cannot be palpated, then what imaging can be used to confirm dx?
CT of pelvis, Endorectal US, MRI of pelvis
Preferred imaging for fistula tract and extent of anal sphincter involvement?
MRI of pelvis w/ and w/o contrast and endosonography
Other indications for MRI of pelvis w/ and w/o contrast and endosonography?
If primary opening hard to find, recurrent fistulas, complex fistulas, esp. if associated w perianal Crohn’s
What test can be used to determine other pathology (malignancy, IBD) related to anorectal abscess symptoms?
Colonoscopy
DDX for anorectal pain and perirectal skin lesions?
Hemorrhoids (thrombosed), anal fistulas, anal fissures, IBD, rectal prolapse, Acute proctitis (STDs), Anal abscesses, Hidradenitis suppurativa, infected inclusion cysts, pilodonal cyst, Bartholin gland abscess in females
Treatment of acute perianal abscess requires what?
Incision and drainage (I&D)
I&D for simple perianal abscesses?
May be treated in ED under local anesthesia
I&D for complex perianal abscesses?
By a surgeon in the OR under general anesthesia
Which perirectal abscesses should be referred to surgical service for I&D?
Ischiorectal, intersphincteric, supralevator
American Society of Colorectal Surgery guidelines suggest what for the role of abx for anorectal abscesses?
A course of empiric abx after I&D ONLY in patients with: Systemic infection/sepsis, Extensive perianal/perineal cellulitis, Diabetes, Immunosuppression, Heart valve abnormalities/prostheses
UpToDate suggestion for abx follwing I&D of anorectal abscesses?
Course of empiric abx for ALL patients after I&D (evidence that such may reduce rate of fistula formation)
What is Goodsall’s rule for surgical planning of anorectal fistulas?
-All fistula tracks w/ external openings within 3cm of anal verge and posterior to a line drawn through the ischial spines travel in a curvilinear fashion to the posterior midline
-All tracks w/ external openings anterior to this line enter the anal canal in a radial fashion
-line of demarcation is depicted as transverse anal line
Do fistula tracks longer than 3 cm from the anal verge necessarily follow Goodsall’s rule?
No, often have an internal opening in the posterior midline regardless of the location of the external opening
If Crohn disease of the perineum is present w/ multiple or complex fistulas, what tx is required?
Surgical tx + additional management with Abx & immunosuppressants
Surgical incision or excision of anal fistulae is indicated for which cases?
Symptomatic cases