Angiotensin Receptor Blockers/ARB's (-"sartan")

Question 1

MoA

Answer 1

1. prevent binding of angiotensin II to the AT2 receptor in the CCT
2. allows for ACE enzyme formation –> bradykinin is able to get inactivated –> no cough or angioedema side effects

Question 2

Clinical Uses

Answer 2

1. patients who are intolerant to ACE inhibitor therapy due to chronic cough and/or development of angioedema (same uses otherwise)
   
   • –> diabetic nepropathy & proteinuria
   • –> HF
   • –> HTN

Question 3

Adverse Effects

Answer 3

1. decreased GFR –> increase in serum creatinine levels (same as ACE inhibitor)
2. hyperkalemia & hyponatremia
3. hypotension
4. **teratogen
   
   • causes renal development abnormalities in fetus

Question 4

Contraindications

Answer 4

1. **bilateral renal artery stenosis patients
2. pregnant women