Angiogenesis

Question 1

growth of new blood vessels

Answer 1

angiogenesis

Question 2

VEGF receptors are found on

Answer 2

endothelial cells

Question 3

VEGF promotes

Answer 3

proliferation, migration, survival, and angiogenesis

Question 4

HIF (hypoxia inducible factor) turns on to stimulate

Answer 4

angiogenesis

Question 5

In a normoxia situation, HIF is removed by

Answer 5

ubiquitation

Question 6

In hypoxia, HIF is phosphorylated and drives expression of genes to promote

Answer 6

angiogenesis

Question 7

ELR+

Answer 7

proangiogenic

Question 8

ELR-

Answer 8

antiangiogenic

Question 9

_____ is an antiangiogenic therapeutic

Answer 9

endostatin

Question 10

Wine is a ____ inhibitor

Answer 10

COX 1

Question 11

Over _____ % of human malignancies are of epithelial origin

Answer 11

90

Question 12

Malignancy is found when epithelial tissues turn into

Answer 12

mesenchymal tissues

Question 13

____ is an established marker for mesenchymal cells

Answer 13

vimentin

Question 14

Ability of cancer cells to metastasize is acquired

Answer 14

early

Question 15

Genes involved exclusively in ____ do not exist

Answer 15

metastasis

Question 16

____ tumors still metastasize

Answer 16

small

Question 17

Oncogenes important in metastasis

Answer 17

RAS, SRC, HER2

Question 18

Hep3 cells formed more metastasis due to

Answer 18

greater intravasation, faster secondary growth

Question 19

Colon

Answer 19

liver

Question 20

breast

Answer 20

bone, lung

Question 21

melanoma

Answer 21

liver, brain, bone