Angioedema Flashcards
What is angioedema and its common association?
Swelling of cutaneous and/or mucosal tissue due to vascular leakage, often associated with urticaria.
What is a key element in the pathophysiology of allergic reactions related to angioedema?
IgE-mediated mast cell activation and degranulation.
What percentage of the population may experience angioedema at some point in their lives?
10-20%.
What are some common signs and symptoms of angioedema?
Swelling of the face, tongue, hands, feet, throat tightness, voice changes, trouble breathing, local burning sensation, and pain.
What should be considered in acute and new-onset angioedema cases?
Potential relationship with food or drug intake, insect stings, or other unusual exposures.
What is a significant characteristic of chronic and recurrent angioedema cases?
Potential triggers, medication use, associated medical history, family history, and past evaluation.
What is the most common type of chronic angioedema?
Idiopathic.
What differentiates pseudoallergic angioedema from allergic angioedema?
Pseudoallergic is not IgE-mediated but has a similar clinical course and presentation.
What is a prototype of non-allergic angioedema?
Hereditary angioedema (HAE).
What is a common treatment response indicator for idiopathic angioedema?
Response to antihistamines, suggesting mast cell activation.
What is the primary characteristic of idiopathic angioedema?
The cause is often unclear.
What is a common treatment for mild to moderate angioedema?
Antihistamines are often used as the first-line treatment.
How is severe angioedema with laryngeal swelling managed?
Close monitoring of the airway and administration of epinephrine are necessary.
What differentiates angioedema from urticaria in terms of skin involvement?
Angioedema involves deeper layers of skin and submucosal tissue, while urticaria affects more superficial layers.
What is a suggested initial intervention for idiopathic recurrent angioedema?
A trial of non-sedating antihistamines administered twice daily.
