Angina Drugs Flashcards
nitroglycerin MOA
vasodilation of blood vessels
relaxation of vasospasm in variant angina
how can you take nitroglycerin
oral (1st pass effect though!), IV, buccal or patch
short acting nitro
isosorbide dinitrate
long acting nitro
isosorbine mononitrate
onset + peak + 1/2 life of nitro
peak– within 4 mins
1/2 life– 5-7 mins
persists for 1 hr
Pt teaching of nitro
no moisture dark package no booze-- severe hypo rotate sites tolerance develops-- drug free @ night D-D interactions-- ED drugs can be life threatening
common SE of nitro
headache, hypo, ortho hypo, tachy
BB MOA
decrease cardiac oxygen demand by slowing down HR and reducing contractility
BB Nsg Considerations
check BP and pulse DM-- masks s/s of hypoglycemia don't stop abruptly avoid in asthma/COPD (cardiac nonselective) monitor for brady and AV heart block
CCB MOA
inhibits the influx of Ca into cells, preventing muscular contraction. leads to vasodilation
chronic angina– causes arteriolar sm relaxation, decreases BP and decreases myocardial demand
CCB SE
hypotension, reflex tachy
what should you monitor with CCBs?
s/s of HF
daily weights
NO grapefruit
watch for brady/AV heart block
MOA for ranolazine
dont’ really know how it works.
given in conjunction with another category
considerations for ranolazine
no grapefruit, decreases incidence of angina and increases exercise tolerance.
AE of ranolazine
prolonged QT intervals
constipation, dizziness, nausea and headache
