angina

Question 1

stable/atherosclerotis angina aka

Answer 1

angina of effort, classic angina, angina pectoris

Question 2

Prinzmetal’s angina aka

Answer 2

rest angina, variant angina, vasospastic angina, angina inversa

Question 3

unstable angina aka

Answer 3

crescendo angina, ACS

Question 4

MOA: irreversibly inhibits COX1 causing dec PG and thromboxane A2 so platelets dont stick

Answer 4

aspirin

Question 5

SE aspirin

Answer 5

SE- inc bleeding, tinnitus, reyes syndrome

Question 6

TxA2?

Answer 6

vasoconstriction and platelet aggregant

Question 7

1st line antiischemic therapy?

Answer 7

beta blockers

Question 8

2nd line antiischemic therapy

Answer 8

CCB

Question 9

_____ is hallmark of any nitrate

Answer 9

HA

Question 10

Only use if beta blockers or CCB are contraindicated

Answer 10

nitrates

Question 11

Big 1st pass metabolism

Answer 11

Isosorbide dinitrate (DN)

Question 12

need nitrate free period

Answer 12

Isosorbide dinitrate (DN)

Question 13

SE- HA, HoTN/orthostatic HoTN

Answer 13

Isosorbide dinitrate (DN)

Question 14

diff btwn Isosorbide mono and dinitrate

Answer 14

mono is the active metabolite of di. It has a high bioavailability and longer half life

Question 15

Ranolazine treats ______

Answer 15

chronic angina

Question 16

MOA: blocks Na from coming into the cell so Ca overload does not occur and coronary blood flow is improved

Answer 16

Ranolazine

Question 17

Lipid lowering therapy

Answer 17

Omega 3 fatty acids
Niacin
Fibrates

Question 18

_________ For pts with CAD and stable ischemic heart disease (SIHD)

Answer 18

lipid lowering therapy

Question 19

2 essential events must occur in ACS

Answer 19

Disruption of atherosclerotic plaque causes platelet aggregation
Platelet rich clot forms

Question 20

Unstable angina is _____ for troponin

Answer 20

-

Question 21

NSTEMI is ____ for troponin

Answer 21

+

Question 22

acs presentation in females

Answer 22

dyspepsia and indigestion

Question 23

Earliest response to vasc injury is ______

Answer 23

vasospasm

Question 24

What triggers platelet activation?

Answer 24

Collagen- exposed by vascular injury
ADP- sec from activated platelets
TXA2- diffuses out of activate platelets (remember ASA blocks this)
Thrombin- formed by coagulation cascade

Question 25

Clopidogrel

Answer 25

P2Y12 inhibitors

Question 26

Prasugrel

Answer 26

P2Y12 inhibitors

Question 27

Ticagrelor

Answer 27

P2Y12 inhibitors

Question 28

Ticlopidine

Answer 28

P2Y12 inhibitors

Question 29

Cangrelor

Answer 29

P2Y12 inhibitors

Question 30

Abciximab

Answer 30

GPIIb/IIIa inhibitors

Question 31

Cilostazol

Answer 31

PDE inhibitors

Question 32

Dipyridamole

Answer 32

PDE inhibitors

Question 33

Eptifibatide

Answer 33

GPIIb/IIIa inhibitors

Question 34

Tirofiban

Answer 34

GPIIb/IIIa inhibitors

Question 35

Dipyridamole/ ASA

Answer 35

PDE inhibitors

Question 36

Progrug activated in the liver by CYP2C19 that irreversibly blocks P2Y12 receptors

Answer 36

Clopidogrel

Question 37

BBW: effectiveness depends on CYP450

Answer 37

Clopidogrel

Question 38

Prodrug that irreversible blocks P2Y12 receptors

Answer 38

Prasugrel

Question 39

Inhibits platelet aggregation faster than clopidogrel

Answer 39

Prasugrel

Question 40

Not a prodrug

Answer 40

cangrelor and Ticagrelor

Question 41

Reversibly binds to platelet ADP P2Y12 receptors

Answer 41

Ticagrelor

Question 42

Acts faster but not as long as clopidogrel or prasugrel

Answer 42

Ticagrelor

Question 43

Significant drug interactions with CYP3A4 inhibitors and inducers

Answer 43

Ticagrelor

Question 44

MOA: Selectively and reversibly binds to P2Y12 receptors

Answer 44

Cangrelor